RT Journal Article
T1 Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis.
A1 Sanabria-de la Torre, Raquel
A1 Fernández-González, Ana
A1 Quiñones-Vico, María I
A1 Montero-Vilchez, Trinidad
A1 Arias-Santiago, Salvador
K1 animal experimentation
K1 atopic dermatitis
K1 bioengineered artificial skin substitutes
K1 fibroblasts
K1 keratinocytes
K1 product testing
K1 psoriasis
K1 regenerative medicine
K1 tissue engineering
K1 transepidermal water loss
AB This review aims to be an update of Bioengineered Artificial Skin Substitutes (BASS) applications. At the first moment, they were created as an attempt to replace native skin grafts transplantation. Nowadays, these in vitro models have been increasing and widening their application areas, becoming important tools for research. This study is focus on the ability to design in vitro BASS which have been demonstrated to be appropriate to develop new products in the cosmetic and pharmacology industry. Allowing to go deeper into the skin disease research, and to analyze the effects provoked by environmental stressful agents. The importance of BASS to replace animal experimentation is also highlighted. Furthermore, the BASS validation parameters approved by the OECD (Organisation for Economic Co-operation and Development) are also analyzed. This report presents an overview of the skin models applicable to skin research along with their design methods. Finally, the potential and limitations of the currently available BASS to supply the demands for disease modeling and pharmaceutical screening are discussed.
SN 2227-9059
YR 2020
FD 2020-10-31
LK https://hdl.handle.net/10668/24789
UL https://hdl.handle.net/10668/24789
LA en
DS RISalud
RD Apr 5, 2025