RT Journal Article
T1 Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer
A1 Garcia-Pinel, Beatriz
A1 Jabalera, Ylenia
A1 Ortiz, Raul
A1 Cabeza, Laura
A1 Jimenez-Lopez, Concepción
A1 Melguizo, Consolación
A1 Prados, Jose
K1 Biomimetics
K1 Nanoparticles
K1 Colon carcinoma
K1 Liposome
K1 Oxaliplatin
K1 Biomimética
K1 Nanopartículas
K1 Liposomas
K1 Oxaliplatino
K1 Neoplasias del colon
AB Current chemotherapy for colorectal cancer (CRC) includes the use of oxaliplatin (Oxa), a first-line cytotoxic drug which, in combination with irinotecan/5-fluorouracil or biologic agents, increases the survival rate of patients. However, the administration of this drug induces side effects that limit its application in patients, making it necessary to develop new tools for targeted chemotherapy. MamC-mediated biomimetic magnetic nanoparticles coupled with Oxa (Oxa-BMNPs) have been previously demonstrated to efficiently reduce the IC50 compared to that of soluble Oxa. However, their strong interaction with the macrophages revealed toxicity and possibility of aggregation. In this scenario, a further improvement of this nanoassembly was necessary. In the present study, Oxa-BMNPs nanoassemblies were enveloped in phosphatidylcholine unilamellar liposomes (both pegylated and non-pegylated). Our results demonstrate that the addition of both a lipid cover and further pegylation improves the biocompatibility and cellular uptake of the Oxa-BMNPs nanoassemblies without significantly reducing their cytotoxic activity in colon cancer cells. In particular, with the pegylated magnetoliposome nanoformulation (a) hemolysis was reduced from 5% to 2%, being now hematocompatibles, (b) red blood cell agglutination was reduced, (c) toxicity in white blood cells was eliminated. This study represents a truly stepforward in this area as describes the production of one of the very few existing nanoformulations that could be used for a local chemotherapy to treat CRC.
PB MDPI
YR 2020
FD 2020-06-24
LK http://hdl.handle.net/10668/3879
UL http://hdl.handle.net/10668/3879
LA en
NO Garcia-Pinel B, Jabalera Y, Ortiz R, Cabeza L, Jimenez-Lopez C, Melguizo C, et al. Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer. Pharmaceutics. 2020 Jun 24;12(6):589
DS RISalud
RD Apr 6, 2025