RT Journal Article
T1 IgE Test in Secretions of Patients with Respiratory Allergy.
A1 Rondon, Carmen
A1 Eguiluz-Gracia, Ibon
A1 Shamji, Mohamed H
A1 Layhadi, Janice A
A1 Salas, Maria
A1 Torres, Maria Jose
A1 Campo, Paloma
K1 Allergen-specific immunotherapy
K1 Allergic
K1 IgE
K1 Local allergic rhinitis
K1 Rhinitis
AB IgE is a key player in multiple inflammatory airway diseases. Ample literature demonstrates its presence in mucosa of patients with allergic rhinitis (AR), local allergic rhinitis (LAR), asthma, or chronic rhinosinusitis with nasal polyposis (CRSwNP). Current evidence shows that high-affinity IgE in blood stream of allergic individuals derives mainly from the mucosae. Also, mucosal synthesis of IgE can occur in the absence of systemic atopy, and may be relevant in atopic and non-atopic phenotypes of rhinitis as demonstrated in LAR. Specific IgE (sIgE) detection varies depending on technique used for sample collection and its measurement. sIgE detection is highly specific for diagnosis of LAR. Moreover, measurement of sIgE in secretions could be useful in monitoring response to allergen-specific immunotherapy in both AR and LAR phenotypes. This review will focus on recent developments in the role of IgE in respiratory diseases, and the clinical implications of its measurement in secretions.
PB Springer
YR 2018
FD 2018-10-13
LK http://hdl.handle.net/10668/13077
UL http://hdl.handle.net/10668/13077
LA en
NO Rondón C, Eguíluz-Gracia I, Shamji MH, Layhadi JA, Salas M, Torres MJ, et al.  IgE Test in Secretions of Patients with Respiratory Allergy. Curr Allergy Asthma Rep. 2018 Oct 13;18(12):67
DS RISalud
RD Apr 11, 2025