TY  - JOUR
AU  - Olmo, Francisco
AU  - Urbanová, Kristína
AU  - Rosales, Maria Jose
AU  - Martín-Escolano, Ruben
AU  - Sánchez-Moreno, Manuel
AU  - Marín, Clotilde
PY  - 2015
DO  - 10.1016/j.ijpddr.2015.05.002
UR  - http://hdl.handle.net/10668/2129
T2  - International Journal for Parasitology. Drugs and Drug Resistance
AB  - In order to identify new compounds to treat Chagas disease during the acute phase with higher activity and lower toxicity than the reference drug benznidazole (Bz), two hydroxyphthalazine derivative compounds were prepared and their trypanocidal...
LA  - en
PB  - Elsevier
KW  - Anti-chagasic
KW  - Chemotherapy
KW  - Trypanosomiasis
KW  - Hydroxyphthalazine derivatives
KW  - Antiparasitarios
KW  - Enfermedad de chagas
KW  - Citometría de flujo
KW  - Concentración 50 inhibidora
KW  - Imagen por resonancia magnética
KW  - Ratones consanguíneos BALB C
KW  - Microscopía
KW  - Parásitos
KW  - Células vero
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiparasitic Agents
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Cercopithecidae::Cercopithecinae::Cercopithecus::Cercopithecus aethiops
KW  - Medical Subject Headings::Diseases::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Trypanosomiasis::Chagas Disease
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cell Separation::Flow Cytometry
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Toxicity Tests::Inhibitory Concentration 50
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaging
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred BALB C
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Microscopy
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Nitro Compounds::Nitroimidazoles
KW  - Medical Subject Headings::Diseases::Parasitic Diseases::Parasitemia
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Invertebrates::Parasites
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Superoxide Dismutase
KW  - Medical Subject Headings::Organisms::Eukaryota::Euglenozoa::Kinetoplastida::Trypanosomatina::Trypanosoma::Trypanosoma cruzi
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Vero Cells
TI  - An in vitro iron superoxide dismutase inhibitor decreases the parasitemia levels of Trypanosoma cruzi in BALB/c mouse model during acute phase.
TY  - research article
ER  -