RT Journal Article
T1 Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy
A1 Hmadcha, Abdelkrim
A1 Martin-Montalvo, Alejandro
A1 Gauthier, Benoit R.
A1 Soria, Bernat
A1 Capilla-Gonzalez, Vivian
K1 Mesenchymal stem cells
K1 Cancer
K1 Cell therapy
K1 Therapeutic agents
K1 Anti-tumor activity
K1 Células madre mesenquimatosas
K1 Neoplasias
K1 Tratamiento basado en trasplante de células y tejidos
K1 Terapéutica
AB Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of studies have shown the beneficial effects of MSC-based therapies to treat different pathologies, including neurological disorders, cardiac ischemia, diabetes, and bone and cartilage diseases. However, the therapeutic potential of MSCs in cancer is still controversial. While some studies indicate that MSCs may contribute to cancer pathogenesis, emerging data reported the suppressive effects of MSCs on cancer cells. Because of this reality, a sustained effort to understand when MSCs promote or suppress tumor development is needed before planning a MSC-based therapy for cancer. Herein, we provide an overview on the therapeutic application of MSCs for regenerative medicine and the processes that orchestrates tissue repair, with a special emphasis placed on cancer, including central nervous system tumors. Furthermore, we will discuss the current evidence regarding the double-edged sword of MSCs in oncological treatment and the latest advances in MSC-based anti-cancer agent delivery systems.
PB Frontiers
YR 2020
FD 2020-02-05
LK http://hdl.handle.net/10668/3685
UL http://hdl.handle.net/10668/3685
LA en
NO Hmadcha A, Martin-Montalvo A, Gauthier BR, Soria B, Capilla-Gonzalez V. Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy. Front Bioeng Biotechnol. 2020 Feb 5;8:43
DS RISalud
RD Apr 8, 2025