%0 Journal Article
%A Navarro-Marí, José María
%A Gómez-Camarasa, Cristina
%A Pérez-Ruiz, Mercedes
%A Sanbonmatsu-Gámez, Sara
%A Pedrosa-Corral, Irene
%A Jiménez-Valera, María
%T Clinic-epidemiologic study of human infection by Granada virus, a new phlebovirus within the sandfly fever Naples serocomplex.
%D 2013
%@ 0002-9637
%U http://hdl.handle.net/10668/1624
%X Granada virus (GRV), a new phlebovirus within the Naples serocomplex, has been recently described in phlebotomine sandflies from Spain. The presence of anti-GRV immunoglobulin G (IgG) antibodies was investigated by indirect fluorescence assay (IFA) and neutralization test (NT) in 920 serum samples from the Granada population. By IFA, an overall GRV seroprevalence of 15.8% (N = 145) was observed, significantly increasing up to 65 years. NT was positive in 18% of anti-GRV IFA-positive samples. IgG antibodies against Toscana virus (TOSV), a hyperendemic phlebovirus within Granada province, were detected in 40% of anti-GRV-positive cases. Anti-GRV IgM antibodies were detected in 36 (6.6%) of 547 acute-phase serum samples from individuals with febrile illness, exanthema, and/or acute respiratory infection. All positives were anti-TOSV IgM-negative. GRV may infect humans, with most cases being asymptomatic. The codetection of anti-GRV and anti-TOSV IgG antibodies could be attributable to cross-reactivity or exposure to the same transmission vector.
%K Immunoglobulina G
%K Immunoglobulina M
%K Anticuerpos víricos
%K Fiebre por Flebótomos
%K Phlebovirus
%K Psychodidae
%K Virus de Nápoles de la Fiebre de la Mosca de los Arenales
%K España
%K Estudios Seroepidemiológicos
%K Andalucia
%~