RT Journal Article
T1 Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes.
A1 Acosta-Herrera, Marialbert
A1 Kerick, Martin
A1 Lopéz-Isac, Elena
A1 Assassi, Shervin
A1 Beretta, Lorenzo
A1 Simeón-Aznar, Carmen Pilar
A1 Ortego-Centeno, Norberto
A1 International SSc Group, 
A1 Proudman, Susanna M
A1 Australian Scleroderma Interest Group (ASIG), 
A1 Hunzelmann, Nicolas
A1 Moroncini, Gianluca
A1 de Vries-Bouwstra, Jeska K
A1 Orozco, Gisela
A1 Barton, Anne
A1 Herrick, Ariane L
A1 Terao, Chikashi
A1 Allanore, Yannick
A1 Brown, Matthew A
A1 Radstake, Timothy Rdj
A1 Fonseca, Carmen
A1 Denton, Christopher P
A1 Mayes, Maureen D
A1 Martin, Javier
K1 autoantibodies
K1 genetic
K1 immune complex diseases
K1 polymorphism
K1 systemic sclerosis
AB The greatest genetic effect reported for systemic sclerosis (SSc) lies in the major histocompatibility complex (MHC) locus. Leveraging the largest SSc genome-wide association study, we aimed to fine-map this region to identify novel human leucocyte antigen (HLA) genetic variants associated with SSc susceptibility and its main clinical and serological subtypes. 9095 patients with SSc and 17 584 controls genome-wide genotyped were used to impute and test single-nucleotide polymorphisms (SNPs) across the MHC, classical HLA alleles and their composite amino acid residues. Additionally, patients were stratified according to their clinical and serological status, namely, limited cutaneous systemic sclerosis (lcSSc), diffuse cutaneous systemic sclerosis (dcSSc), anticentromere (ACA), antitopoisomerase (ATA) and anti-RNApolIII autoantibodies (ARA). Sequential conditional analyses showed nine SNPs, nine classical alleles and seven amino acids that modelled the observed associations with SSc. This confirmed previously reported associations with HLA-DRB1*11:04 and HLA-DPB1*13:01, and revealed a novel association of HLA-B*08:01. Stratified analyses showed specific associations of HLA-DQA1*02:01 with lcSSc, and an exclusive association of HLA-DQA1*05:01 with dcSSc. Similarly, private associations were detected in HLA-DRB1*08:01 and confirmed the previously reported association of HLA-DRB1*07:01 with ACA-positive patients, as opposed to the HLA-DPA1*02:01 and HLA-DQB1*03:01 alleles associated with ATA presentation. This study confirms the contribution of HLA class II and reveals a novel association of HLA class I with SSc, suggesting novel pathways of disease pathogenesis. Furthermore, we describe specific HLA associations with SSc clinical and serological subtypes that could serve as biomarkers of disease severity and progression.
YR 2021
FD 2021-04-01
LK http://hdl.handle.net/10668/17969
UL http://hdl.handle.net/10668/17969
LA en
DS RISalud
RD Apr 5, 2025