RT Journal Article
T1 Serum potassium dynamics during acute heart failure hospitalization.
A1 Caravaca Perez, Pedro
A1 González-Juanatey, José R
A1 Nuche, Jorge
A1 Morán Fernández, Laura
A1 Lora Pablos, David
A1 Alvarez-García, Jesús
A1 Bascompte Claret, Ramón
A1 Martínez Selles, Manuel
A1 Vázquez García, Rafael
A1 Martínez Dolz, Luis
A1 Cobo-Marcos, Marta
A1 Pascual Figal, Domingo
A1 Crespo-Leiro, Maria G
A1 Nuñez Villota, Julio
A1 Cinca Cuscullola, Juan
A1 Delgado, Juan F
K1 Dyskalemia
K1 Heart failure
K1 Hyperkalemia
K1 Hypokalemia
K1 Potassium
AB Available information about prognostic implications of potassium levels alteration in the setting of acute heart failure (AHF) is scarce. We aim to describe the prevalence of dyskalemia (hypo or hyperkalemia), its dynamic changes during AHF-hospitalization, and its long-term clinical impact after hospitalization. We analyzed 1779 patients hospitalized with AHF who were included in the REDINSCOR II registry. Patients were classified in three groups, according to potassium levels both on admission and discharge: hypokalemia (potassium  5 mEq/L). The prevalence of hypokalemia and hyperkalemia on admission was 8.2 and 4.6%, respectively, and 6.4 and 2.7% at discharge. Hyperkalemia on admission was associated with higher in-hospital mortality (OR = 2.32 [95% CI: 1.04-5.21] p = 0.045). Among patients with hypokalemia on admission, 79% had normalized potassium levels at discharge. In the case of patients with hyperkalemia on admission, 89% normalized kalemia before discharge. In multivariate Cox regression, dyskalemia was associated with higher 12-month mortality, (HR = 1.48 [95% CI, 1.12-1.96], p = 0.005). Among all patterns of dyskalemia persistent hypokalemia (HR = 3.17 [95% CI: 1.71-5.88]; p  Potassium levels alterations are frequent and show a dynamic behavior during AHF admission. Hyperkalemia on admission is an independent predictor of higher in-hospital mortality. Furthermore, persistent hypokalemia and transient hyperkalemia on admission are independent predictors of 12-month mortality.
YR 2020
FD 2020-10-17
LK http://hdl.handle.net/10668/19830
UL http://hdl.handle.net/10668/19830
LA en
DS RISalud
RD Apr 11, 2025