TY  - JOUR
AU  - Shukla, Surendra K
AU  - Purohit, Vinee
AU  - Mehla, Kamiya
AU  - Gunda, Venugopal
AU  - Chaika, Nina V
AU  - Vernucci, Enza
AU  - King, Ryan J
AU  - Abrego, Jaime
AU  - Goode, Gennifer D
AU  - Dasgupta, Aneesha
AU  - Illies, Alysha L
AU  - Gebregiworgis, Teklab
AU  - Dai, Bingbing
AU  - Augustine, Jithesh J
AU  - Murthy, Divya
AU  - Attri, Kuldeep S
AU  - Mashadova, Oksana
AU  - Grandgenett, Paul M
AU  - Powers, Robert
AU  - Ly, Quan P
AU  - Lazenby, Audrey J
AU  - Grem, Jean L
AU  - Yu, Fang
AU  - Matés, José M
AU  - Asara, John M
AU  - Kim, Jung-Whan
AU  - Hankins, Jordan H
AU  - Weekes, Colin
AU  - Hollingsworth, Michael A
AU  - Serkova, Natalie J
AU  - Sasson, Aaron R
AU  - Fleming, Jason B
AU  - Oliveto, Jennifer M
AU  - Lyssiotis, Costas A
AU  - Cantley, Lewis C
AU  - Berim, Lyudmyla
AU  - Singh, Pankaj K
PY  - 2017
DO  - 10.1016/j.ccell.2017.06.004
UR  - http://hdl.handle.net/10668/11393
T2  - Cancer cell
AB  - Poor response to cancer therapy due to resistance remains a clinical challenge. The present study establishes a widely prevalent mechanism of resistance to gemcitabine in pancreatic cancer, whereby increased glycolytic flux leads to glucose addiction...
LA  - en
KW  - HIF-1α
KW  - MUC1
KW  - cancer metabolism
KW  - chemotherapy resistance
KW  - gemcitabine
KW  - mucin
KW  - non-oxidative pentose phosphate pathway
KW  - nucleotide synthesis
KW  - pancreatic cancer
KW  - pyrimidine biosynthesis
KW  - Carbon
KW  - Deoxycytidine
KW  - Digoxin
KW  - Drug Resistance, Neoplasm
KW  - Glucose
KW  - Humans
KW  - Hypoxia-Inducible Factor 1, alpha Subunit
KW  - Mucin-1
KW  - Pancreatic Neoplasms
KW  - Pentose Phosphate Pathway
KW  - Prognosis
KW  - Pyrimidines
KW  - Signal Transduction
KW  - Gemcitabine
TI  - MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.
TY  - research article
VL  - 32
ER  -