RT Journal Article
T1 Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro.
A1 Rodriguez-Pacheco, F
A1 Novelle, M G
A1 Vazquez, M J
A1 Garcia-Escobar, E
A1 Soriguer, F
A1 Rojo-Martinez, G
A1 García-Fuentes, E
A1 Malagon, M M
A1 Dieguez, C
K1 Resistina
K1 Antagonistas de la insulina
K1 Inflamación
K1 Inmunidad
K1 Ingestión de Alimentos
K1 Gónadas
K1 Hormona del crecimiento
K1 Ratas
K1 Hipófisis
K1 Lipogénesis
AB The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary cells cultures with the adipokine. Although adipose tissue is the primary source of resistin, it is also expressed in other tissues, including the pituitary. The aim of this study is to investigate the possible action of resistin on the lipid metabolism in the pituitary gland in vivo (rats in two different nutritional status, fed and fast, treated with resistin on acute and a chronic way) and in vitro (adenopituitary cell cultures treated with the adipokine). Here, by a combination of in vivo and in vitro experimental models, we demonstrated that central acute and chronic administration of resistin enhance mRNA levels of the lipid metabolic enzymes which participated on lipolysis and moreover inhibiting mRNA levels of the lipid metabolic enzymes involved in lipogenesis. Taken together, our results demonstrate for the first time that resistin has a regulatory role on lipid metabolism in the pituitary gland providing a novel insight in relation to the mechanism by which this adipokine can participate in the integrated control of lipid metabolism.
PB Hindawi Publishing Corporation
SN 0962-9351
YR 2013
FD 2013
LK http://hdl.handle.net/10668/1440
UL http://hdl.handle.net/10668/1440
LA en
NO Rodriguez-Pacheco F, Novelle MG, Vazquez MJ, Garcia-Escobar E, Soriguer F, Rojo-Martinez G, et al. Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro. Mediators Inflamm.; 2013:479739
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 4, 2025