RT Journal Article
T1 Blood Neutrophil Counts Define Specific Clusters of Bronchiectasis Patients: A Hint to Differential Clinical Phenotypes.
A1 Wang, Xuejie
A1 Olveira, Casilda
A1 Giron, Rosa
A1 Garcia-Clemente, Marta
A1 Maiz, Luis
A1 Sibila, Oriol
A1 Golpe, Rafael
A1 Menendez, Rosario
A1 Rodriguez-Lopez, Juan
A1 Prados, Concepcion
A1 Martinez-Garcia, Miguel Angel
A1 Rodriguez, Juan Luis
A1 de-la-Rosa, David
A1 Qin, Liyun
A1 Duran, Xavier
A1 Garcia-Ojalvo, Jordi
A1 Barreiro, Esther
K1 Biostatistics analyses
K1 Bronchiectasis
K1 Bronchiectasis severity scores
K1 Clinical outcomes
K1 Multivariate analyses
K1 Neutrophilic inflammation
K1 Phenotypic clusters
AB We sought to investigate differential phenotypic characteristics according to neutrophil counts, using a biostatistics approach in a large-cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 1034 patients who met the inclusion criteria were clustered into two groups on the basis of their blood neutrophil levels. Using the Mann-Whitney U test to explore potential differences according to FACED and EFACED scores between the two groups, a neutrophil count of 4990 cells/µL yielded the most balanced cluster sizes: (1) above-threshold (n = 337) and (2) below-threshold (n = 697) groups. Patients above the threshold showed significantly worse lung function parameters and nutritional status, while systemic inflammation levels were higher than in the below-threshold patients. In the latter group, the proportions of patients with mild disease were greater, while a more severe disease was present in the above-threshold patients. According to the blood neutrophil counts using biostatistics analyses, two distinct clinical phenotypes of stable patients with non-CF bronchiectasis were defined. Patients falling into the above-threshold cluster were more severe. Severity was characterized by a significantly impaired lung function parameters and nutritional status, and greater systemic inflammation. Phenotypic profiles of bronchiectasis patients are well defined as a result of the cluster analysis of combined systemic and respiratory variables.
PB MDPI
SN 2227-9059
YR 2022
FD 2022-04-30
LK http://hdl.handle.net/10668/20829
UL http://hdl.handle.net/10668/20829
LA en
NO Wang X, Olveira C, Girón R, García-Clemente M, Máiz L, Sibila O,  et al. Blood Neutrophil Counts Define Specific Clusters of Bronchiectasis Patients: A Hint to Differential Clinical Phenotypes. Biomedicines. 2022 Apr 30;10(5):1044
NO This study has been supported by Project FIS 18/00075 funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union; Project FIS 21/00215 funded by Instituto de Salud Carlos III and co-funded by the European Union; CIBERES 2021 funded by Instituto de Salud Carlos III (ISCIII); Sociedad Española de Neumología y Cirugía Torácica: SEPAR2020; Zambon (Spain): 2020; Ministerio de Ciencia y Tecnología: PGC 2018-101251-B-I00; Ministerio de Ciencia y Tecnología: CEX2018-000792-M.
DS RISalud
RD Apr 7, 2025