RT Journal Article
T1 Mitochondrial haplogroups and polymorphisms reveal no association with sporadic prostate cancer in a southern European population.
A1 Álvarez-Cubero, María Jesús
A1 Saiz Guinaldo, María
A1 Martínez-González, Luís Javier
A1 Álvarez Merino, Juan Carlos
A1 Cózar Olmo, José Manuel
A1 Lorente Acosta, José Antonio
K1 Prostate-Specific Antigen
K1 DNA, Mitochondrial
K1 Anciano
K1 ADN Mitocondrial
K1 Estudios de Casos y Controles
K1 Predisposición Genética a la Enfermedad
K1 Genotipo
K1 Haplotipos
K1 Humanos
K1 Masculino
K1 Mitocondrias
K1 Oportunidad Relativa
K1 Polimorfismo Genético
K1 Antígeno Prostático Específico
K1 Análisis de Secuencia de ADN
K1 España
AB BACKGROUNDIt is known that mitochondria play an important role in certain cancers (prostate, renal, breast, or colorectal) and coronary disease. These organelles play an essential role in apoptosis and the production of reactive oxygen species; in addition, mtDNA also reveals the history of populations and ancient human migration. All these events and variations in the mitochondrial genome are thought to cause some cancers, including prostate cancer, and also help us to group individuals into common origin groups. The aim of the present study is to analyze the different haplogroups and variations in the sequence in the mitochondrial genome of a southern European population consisting of subjects affected (n = 239) and non-affected (n = 150) by sporadic prostate cancer.METHODOLOGY AND PRINCIPAL FINDINGSUsing primer extension analysis and DNA sequencing, we identified the nine major European haplogroups and CR polymorphisms. The frequencies of the haplogroups did not differ between patients and control cohorts, whereas the CR polymorphism T16356C was significantly higher in patients with PC compared to the controls (p = 0.029). PSA, staging, and Gleason score were associated with none of the nine major European haplogroups. The CR polymorphisms G16129A (p = 0.007) and T16224C (p = 0.022) were significantly associated with Gleason score, whereas T16311C (p = 0.046) was linked with T-stage.CONCLUSIONS AND SIGNIFICANCEOur results do not suggest that mtDNA haplogroups could be involved in sporadic prostate cancer etiology and pathogenesis as previous studies performed in middle Europe population. Although some significant associations have been obtained in studying CR polymorphisms, further studies should be performed to validate these results.
PB Public Library of Science
YR 2012
FD 2012-07-17
LK http://hdl.handle.net/10668/766
UL http://hdl.handle.net/10668/766
LA en
NO Álvarez-Cubero MJ, Saiz Guinaldo M, Martínez-González LJ, Álvarez Merino JC, Cózar Olmo JM, Acosta JA. Mitochondrial haplogroups and polymorphisms reveal no association with sporadic prostate cancer in a southern European population. PLoS ONE. 2012; 7(7):e41201
NO Journal Article;
DS RISalud
RD Apr 19, 2025