RT Journal Article
T1 Oral Nutritional Supplements in Adults with Cystic Fibrosis: Effects on Intake, Levels of Fat-Soluble Vitamins, and Bone Remodeling Biomarkers
A1 Contreras-Bolívar, Victoria
A1 Olveira, Casilda
A1 Porras, Nuria
A1 Abuín-Fernández, José
A1 García-Olivares, María
A1 Sánchez-Torralvo, Francisco José
A1 Girón, María Victoria
A1 Ruiz-García, Ignacio
A1 Olveira, Gabriel
K1 Cystic fibrosis
K1 Oral nutritional supplements (ONS)
K1 Nutrition
K1 Malnutrition
K1 Osteocalcin
K1 Body mass index
K1 Vitamins
K1 Body composition
K1 Bone remodeling
K1 Body weight
K1 Biomarkers
K1 Nutritional status
K1 Fibrosis quística
K1 Nutrición
K1 Desnutrición
K1 Osteocalcina
K1 Índice de masa corporal
K1 Vitaminas
K1 Composición corporal
K1 Remodelación ósea
K1 Peso corporal
K1 Biomarcadores
K1 Estado nutricional
AB Background: The use of oral nutritional supplements (ONS) is common practice in patients suffering from cystic fibrosis (CF). We aimed to describe the rate of ONS use to assess their contribution to dietary intake and to determine if they are associated with respiratory status, body composition, muscle strength, bone mineral density (BMD), bone remodeling biomarkers, and plasmatic levels of vitamins.Methods: Cross-sectional study. Patients were clinically stable adults recruited from the CF unit. A 4-day prospective dietary questionnaire was conducted; in addition to respiratory variables, body composition, and BMD (through densitometry, DXA), muscle strength (JAMAR dynamometer), fat-soluble vitamins, and bone remodeling biomarkers (vitamins A, D, and E; osteocalcin, OC; undercarboxylated osteocalcin, ucOC; degradation of the C-terminal telopeptides of type I collagen, CTX; and receptor activator of nuclear factor-kappaB ligand, RANKL) were also evaluated.Results: The study included 59 subjects with CF (57.6% female, mean age 29.3 ± 9.4 years, and BMI 22.0 ± 3.6 kg/m2). In this study, 22% (13) patients were taking ONS and presented, compared with those not taking them, significantly more total and mild exacerbations and lower BMI; moreover, they showed a significantly higher total daily calorie intake in addition to a higher consumption of carbohydrates, proteins, and lipids per kg of body weight, omega-3 fatty acids, and vitamins A, D, and E. Vitamin E plasmatic levels were significantly higher in the group on ONS, as was the case with RANKL; finally, a lower rate of vitamin D deficiency was also found.Conclusions: ONS were used by patients with worse respiratory and nutritional statuses and their use was associated with a higher intake of macro- and micronutrients and with better plasmatic levels of fat-soluble vitamins.
PB MDPI
YR 2021
FD 2021-02-19
LK http://hdl.handle.net/10668/4164
UL http://hdl.handle.net/10668/4164
LA en
NO Contreras-Bolívar V, Olveira C, Porras N, Abuín-Fernández J, García-Olivares M, Sánchez-Torralvo FJ, et al. Oral Nutritional Supplements in Adults with Cystic Fibrosis: Effects on Intake, Levels of Fat-Soluble Vitamins, and Bone Remodeling Biomarkers. Nutrients. 2021 Feb 19;13(2):669
DS RISalud
RD Apr 7, 2025