RT Journal Article
T1 The role of exosomes on colorectal cancer: A review.
A1 Ruiz-Lopez, Lidia
A1 Blancas, Isabel
A1 Garrido, Jose M
A1 Mut-Salud, Nuria
A1 Moya-Jodar, Marta
A1 Osuna, Antonio
A1 Rodriguez-Serrano, Fernando
K1 biomarkers
K1 colorectal cancer
K1 exosomes
K1 intercellular communication
K1 oncogenic transformation
AB Exosomes are extracellular microvesicles released from cells, which are involved in many biological and pathological processes, mainly because of their role in intercellular communication. Exosomes derived from colorectal cancer (CRC) cells are related to oncogenesis, tumor cell survival, chemo-resistance, and metastasis. The role of the exosomes in these processes involves the transfer of proteins, RNAs, or mutant versions of proto-oncogenes to the target cells. In recent years, great efforts have been made to identify useful biomarkers in CRC exosomes for diagnosis, prediction of prognosis, and treatment response. This review focuses on recent studies on CRC exosomes, considering isolation, cargo, biomarkers, and the effects of exosomes on the development and progression of CRC, including resistance to antitumor therapy.
PB John Wiley & Sons, Inc.
YR 2017
FD 2017-11-10
LK http://hdl.handle.net/10668/11820
UL http://hdl.handle.net/10668/11820
LA en
NO Ruiz-López L, Blancas I, Garrido JM, Mut-Salud N, Moya-Jódar M, Osuna A, et al.  The role of exosomes on colorectal cancer: A review. J Gastroenterol Hepatol. 2018 Apr;33(4):792-799.
NO This study was supported by the Ministry of Economy and Com-petitiveness (Project CTQ2014-56611-R), the Regional Govern-ment of Andalusia (Project P11-CTS-7651), and Ramón ArecesFoundation (Madrid, Spain).
DS RISalud
RD Apr 6, 2025