%0 Journal Article
%A Yung, Diana E
%A Rondonotti, Emanuele
%A Giannakou, Andry
%A Avni, Tomer
%A Rosa, Bruno
%A Toth, Ervin
%A Lucendo, Alfredo J
%A Sidhu, Reena
%A Beaumont, Hanneke
%A Ellul, Pierre
%A Negreanu, Lucian
%A Jiménez-Garcia, Victoria Alejandra
%A McNamara, Deidre
%A Kopylov, Uri
%A Elli, Luca
%A Triantafyllou, Konstantinos
%A Shibli, Fahmi
%A Riccioni, Maria Elena
%A Bruno, Mauro
%A Dray, Xavier
%A Plevris, John N
%A Koulaouzidis, A
%A And the Capsule Endoscopy in Young Patients with IDA research group
%A Argüelles-Arias, Federico
%A Becq, Aymeric
%A Branchi, Federica
%A Tejero-Bustos, María Ángeles
%A Cotter, Jose
%A Eliakim, Rami
%A Ferretti, Francesca
%A Gralnek, Ian M
%A Herrerias-Gutierrez, Juan Manuel
%A Hussey, Mary
%A Jacobs, Maarten
%A Johansson, Gabriele Wurm
%A McAlindon, Mark
%A Montiero, Sara
%A Nemeth, Artur
%A Pennazio, Marco
%A Rattehalli, Deepa
%A Stemate, Ana
%A Tortora, Annalisa
%A Tziatzios, Georgios
%T Capsule endoscopy in young patients with iron deficiency anaemia and negative bidirectional gastrointestinal endoscopy.
%D 2017
%@ 2050-6406
%U http://hdl.handle.net/10668/11831
%X Recent data imply young patients (age ≤50 years) undergoing small-bowel (SB) capsule endoscopy (CE) for iron deficiency anaemia (IDA) show higher diagnostic yield (DY) for sinister pathology. We aimed to investigate DY of CE in a large cohort of young IDA patients, and evaluate factors predicting significant SB pathology. This was a retrospective, multicentre study (2010-2015) in consecutive, young patients (≤50 years) from 18 centres/12 countries, with negative bidirectional gastrointestinal (GI) endoscopy undergoing SBCE for IDA. Exclusion criteria: previous/ongoing obscure-overt GI bleeding; age 50 years; comorbidities associated with IDA. Data retrieved: SBCE indications; prior investigations; medications; SBCE findings; final diagnosis. Clinical and laboratory data were analysed by multivariate logistic regression. Data on 389 young IDA patients were retrieved. In total, 169 (43.4%) were excluded due to incomplete clinical data; data from 220 (122F/98M; mean age 40.5 ± 8.6 years) patients were analysed. Some 71 patients had at least one clinically significant SBCE finding (DY: 32.3%). They were divided into two groups: neoplastic pathology (10/220; 4.5%), and non-neoplastic but clinically significant pathology (61/220; 27.7%). The most common significant but non-neoplastic pathologies were angioectasias (22/61) and Crohn's disease (15/61). On multivariate analysis, weight loss and lower mean corpuscular volume(MCV) were associated with significant SB pathology (OR: 3.87; 95%CI: 1.3-11.3; p = 0.01; and OR: 0.96; 95%CI: 0.92-0.99; p = 0.03; respectively). Our model also demonstrates association between use of antiplatelets and significant SB pathology, although due to the small number of patients, definitive conclusions cannot be drawn. In IDA patients ≤50 years with negative bidirectional GI endoscopy, overall DY of SBCE for clinically significant findings was 32.3%. Some 5% of our cohort was diagnosed with SB neoplasia; lower MCV or weight loss were associated with higher DY for SB pathology.
%K Capsule endoscopy
%K iron deficiency anaemia
%K neoplasia
%K small bowel
%K young
%~