RT Journal Article
T1 Evaluation of Novel Doxorubicin-Loaded Magnetic Wax Nanocomposite Vehicles as Cancer Combinatorial Therapy Agents.
A1 Jiménez-López, Julia
A1 García-Hevia, Lorena
A1 Melguizo, Consolación
A1 Prados, Jose
A1 Bañobre-López, Manuel
A1 Gallo, Juan
K1 3D in vitro models
K1 combinatorial therapy
K1 drug delivery
K1 magnetic hyperthermia
K1 magnetic nanocomposites
AB The development of nanotechnology-based solutions for cancer at a preclinical level advances at an astounding pace. So far, clinical translation of these new developments has not been able to keep the pace due to a range of different reasons. One of them is the mismatch between in vitro and in vivo results coming from the expected difference in complexity. To overcome this problem, extensive characterisation using advanced in vitro models can lead to stronger preliminary data to face in vivo tests. Here, a comprehensive in vitro validation of a combinatorial therapy nanoformulation against solid tumours is presented. The information extracted from the different in vitro models highlights the importance of advanced 3D models to fully understand the potential of this type of complex drugs.
SN 1999-4923
YR 2020
FD 2020-07-07
LK https://hdl.handle.net/10668/28101
UL https://hdl.handle.net/10668/28101
LA en
DS RISalud
RD Apr 18, 2025