%0 Journal Article
%A Martinez-Tellez, Borja
%A Sanchez-Delgado, Guillermo
%A Garcia-Rivero, Yolanda
%A Alcantara, Juan M A
%A Martinez-Avila, Wendy D
%A Muñoz-Hernandez, Maria V
%A Olza, Josune
%A Boon, Mariëtte R
%A Rensen, Patrick C N
%A Llamas-Elvira, Jose M
%A Ruiz, Jonatan R
%T A New Personalized Cooling Protocol to Activate Brown Adipose Tissue in Young Adults.
%D 2017
%@ 1664-042X
%U http://hdl.handle.net/10668/11828
%X Brown adipose tissue (BAT) activity is induced when humans are exposed to cold. Therefore, cold exposure prior to the 18F-FDG-PET/CT scan is used as a tool to quantify BAT. Several cooling protocols, including fixed and personalized ones are currently in use. The aim of the present study was to determine the effect of a new personalized cooling protocol where the shivering threshold was measured on a separate day, on BAT volume and activity in young adults. A total of 47 adults (n = 28 women) aged 22 ± 2 years participated in the study. We determined participants' shivering threshold (visually and self-reported) using a water perfused cooling vest in an air-conditioned cold room. 48-72 h later, participants wore the cooling vest set at ~4°C above the shivering threshold for 60 min prior to injection of 18F-FDG and ~5°C above the shivering threshold for ~60 min after injection, until PET/CT scan. We quantified BAT following BARCIST 1.0 recommendations. We identified 40 participants (85%, n = 25 women) as PET+ and 7 (n = 3 women) as PET-. The PET+ group presented significantly higher BAT volume and activity than PET- group (all P
%K PET/CT scan
%K body temperature
%K cooling vest
%K glucose uptake
%K thermal perception
%~