RT Journal Article
T1 Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
A1 Karavasiloglou, Nena
A1 Hüsing, Anika
A1 Masala, Giovanna
A1 van Gils, Carla H.
A1 Turzanski Fortner, Renée
A1 Chang-Claude, Jenny
A1 Huybrechts, Inge
A1 Weiderpass, Elisabete
A1 Gunter, Marc
A1 Arveux, Patrick
A1 Fournier, Agnès
A1 Kvaskoff, Marina
A1 Tjønneland, Anne
A1 Kyrø, Cecilie
A1 Dahm, Christina C.
A1 Vistisen, Helene Tilma
A1 Bakker, Marije F.
A1 Sanchez-Perez, Maria-Jose
A1 Chirlaque López, María Dolores
A1 Santiuste, Carmen
A1 Ardanaz, Eva
A1 Menéndez, Virginia
A1 Agudo, Antonio
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 La Vecchia, Carlo
A1 Peppa, Eleni
A1 Palli, Domenico
A1 Agnoli, Claudia
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Butt, Salma Tunå
A1 Borgquist, Signe
A1 Skeie, Guri
A1 Schulze, Matthias
A1 Key, Timothy
A1 Khaw, Kay-Tee
A1 Tsilidis, Kostantinos K.
A1 Ellingjord-Dale, Merete
A1 Riboli, Elio
A1 Kaaks, Rudolf
A1 Dossus, Laure
A1 Rohrmann, Sabine
A1 Kühn, Tilman
K1 In situ breast cancer
K1 Cohort
K1 Lifestyle
K1 Prevention
K1 Lifestyle score
K1 Breast carcinoma in situ
K1 Carcinoma de mama in situ
K1 Estudios de cohortes
K1 Cohort studies
K1 Life style
K1 Estilo de vida
AB Background: Even though in situ breast cancer (BCIS) accounts for a large proportion of the breast cancers diagnosed, few studies have investigated potential risk factors for BCIS. Their results suggest that some established risk factors for invasive breast cancer have a similar impact on BCIS risk, but large population-based studies on lifestyle factors and BCIS risk are lacking. Thus, we investigated the association between lifestyle and BCIS risk within the European Prospective Investigation into Cancer and Nutrition cohort.Methods: Lifestyle was operationalized by a score reflecting the adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations. The recommendations utilized in these analyses were the ones pertinent to healthy body weight, physical activity, consumption of plant-based foods, energy-dense foods, red and processed meat, and sugary drinks and alcohol, as well as the recommendation on breastfeeding. Cox proportional hazards regression was used to assess the association between lifestyle score and BCIS risk. The results were presented as hazard ratios (HR) and corresponding 95% confidence intervals (CI).Results: After an overall median follow-up time of 14.9 years, 1277 BCIS cases were diagnosed. Greater adherence to the WCRF/AICR cancer prevention recommendations was not associated with BCIS risk (HR = 0.98, 95% CI 0.93-1.03; per one unit of increase; multivariable model). An inverse association between the lifestyle score and BCIS risk was observed in study centers, where participants were recruited mainly via mammographic screening and attended additional screening throughout follow-up (HR = 0.85, 95% CI 0.73-0.99), but not in the remaining ones (HR = 0.99, 95% CI 0.94-1.05).Conclusions: While we did not observe an overall association between lifestyle and BCIS risk, our results indicate that lifestyle is associated with BCIS risk among women recruited via screening programs and with regular screening participation. This suggests that a true inverse association between lifestyle habits and BCIS risk in the overall cohort may have been masked by a lack of information on screening attendance. The potential inverse association between lifestyle and BCIS risk in our analyses is consistent with the inverse associations between lifestyle scores and breast cancer risk reported from previous studies.
PB BioMed Central Ltd.
YR 2019
FD 2019-12-02
LK http://hdl.handle.net/10668/3174
UL http://hdl.handle.net/10668/3174
LA en
NO Karavasiloglou N, Hüsing A, Masala G, van Gils CH, Turzanski Fortner R, Chang-Claude J, et al. Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. BMC Med. 2019 Dec 2;17(1):221.
DS RISalud
RD Apr 5, 2025