RT Journal Article
T1 Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients.
A1 Baldelli, Luca
A1 Schade, Sebastian
A1 Jesús, Silvia
A1 Schreglmann, Sebastian R
A1 Sambati, Luisa
A1 Gómez-Garre, Pilar
A1 Halsband, Claire
A1 Calandra-Buonaura, Giovanna
A1 Adarmes-Gómez, Astrid Daniela
A1 Sixel-Döring, Friederike
A1 Zenesini, Corrado
A1 Pirazzini, Chiara
A1 Garagnani, Paolo
A1 Bacalini, Maria Giulia
A1 Bhatia, Kailash P
A1 Cortelli, Pietro
A1 Mollenhauer, Brit
A1 Franceschi, Claudio
A1 PROPAG-AGEING consortium, 
A1 Mir, Pablo
A1 Trenkwalder, Claudia
A1 Provini, Federica
AB A prodromal phase of Parkinson's disease (PD) may precede motor manifestations by decades. PD patients' siblings are at higher risk for PD, but the prevalence and distribution of prodromal symptoms are unknown. The study objectives were (1) to assess motor and non-motor features estimating prodromal PD probability in PD siblings recruited within the European PROPAG-AGEING project; (2) to compare motor and non-motor symptoms to the well-established DeNoPa cohort. 340 PD siblings from three sites (Bologna, Seville, Kassel/Goettingen) underwent clinical and neurological evaluations of PD markers. The German part of the cohort was compared with German de novo PD patients (dnPDs) and healthy controls (CTRs) from DeNoPa. Fifteen (4.4%) siblings presented with subtle signs of motor impairment, with MDS-UPDRS-III scores not clinically different from CTRs. Symptoms of orthostatic hypotension were present in 47 siblings (13.8%), no different to CTRs (p = 0.072). No differences were found for olfaction and overall cognition; German-siblings performed worse than CTRs in visuospatial-executive and language tasks. 3/147 siblings had video-polysomnography-confirmed REM sleep behavior disorder (RBD), none was positive on the RBD Screening Questionnaire. 173/300 siblings had
SN 2373-8057
YR 2021
FD 2021-09-07
LK http://hdl.handle.net/10668/18499
UL http://hdl.handle.net/10668/18499
LA en
DS RISalud
RD Apr 6, 2025