%0 Journal Article
%A Torres-Macho, Juan
%A Sánchez-Fernández, Marcos
%A Arnanz-González, Irene
%A Tung-Chen, Yale
%A Franco-Moreno, Ana Isabel
%A Duffort-Falcó, Mercedes
%A Beltrán-Romero, Luis
%A Rodríguez-Suaréz, Santiago
%A Bernabeu-Wittel, Máximo
%A Urbano, Elena
%A Méndez-Bailon, Manuel
%A Roque-Rojas, Fernando
%A García-Guijarro, Elena
%A García-Casasola, Gonzalo
%T Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study).
%D 2021
%@ 2077-0383
%U https://hdl.handle.net/10668/28216
%X The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted to hospital due to COVID-19. The serial LUS protocol included two examinations (0-48 h and 72-96 h after admission) using a 10-zones sequence, and a 0 to 5 severity score. Primary combined endpoint was death or the need for invasive mechanical ventilation. Calibration (Hosmer-Lemeshow test and calibration curves), and discrimination power (area under the ROC curve) of both ultrasound exams (SCORE1 and 2), and their difference (DIFFERENTIAL-SCORE) were performed. A total of 469 patients (54.2% women, median age 60 years) were included. The primary endpoint occurred in 51 patients (10.9%). Probability risk tertiles of SCORE1 and SCORE2 (0-11 points, 12-24 points, and ≥25 points) obtained a high calibration. SCORE-2 showed a higher discrimination power than SCORE-1 (AUC 0.72 (0.58-0.85) vs. 0.61 (0.52-0.7)). The DIFFERENTIAL-SCORE showed a higher discrimination power than SCORE-1 and SCORE-2 (AUC 0.78 (0.66-0.9)). An algorithm for clinical decision-making is proposed. Serial lung ultrasound performing two examinations during the first days of hospitalization is an accurate strategy for predicting clinical deterioration of patients with COVID-19.
%K COVID-19
%K lung ultrasound
%K pneumonia
%K point-of-care ultrasound
%K prognosis
%~