TY  - JOUR
AU  - Del Campo, José A
AU  - García-Valdecasas, Marta
AU  - Gil-Gómez, Antonio
AU  - Rojas, Ángela
AU  - Gallego, Paloma
AU  - Ampuero, Javier
AU  - Gallego-Durán, Rocío
AU  - Pastor, Helena
AU  - Grande, Lourdes
AU  - Padillo, Francisco J
AU  - Muntané, Jordi
AU  - Romero-Gómez, Manuel
PY  - 2018
DO  - 10.1371/journal.pone.0191805
UR  - http://hdl.handle.net/10668/12068
T2  - PloS one
AB  - Hepatitis C virus (HCV) infection has been related to increased risk of development of hepatocellular carcinoma (HCC) while metformin (M) and statins treatment seemed to protect against HCC development. In this work, we aim to identify the mechanisms...
LA  - en
KW  - Autophagy
KW  - Biomarkers, Tumor
KW  - Carcinoma, Hepatocellular
KW  - Caspase 3
KW  - Cell Line
KW  - Cell Proliferation
KW  - Cells, Cultured
KW  - Drug Therapy, Combination
KW  - Gene Expression
KW  - Hepacivirus
KW  - Hepatitis C, Chronic
KW  - Hepatocytes
KW  - Humans
KW  - Liver Neoplasms
KW  - Metformin
KW  - Microtubule-Associated Proteins
KW  - PTEN Phosphohydrolase
KW  - Simvastatin
KW  - TOR Serine-Threonine Kinases
KW  - Tumor Protein, Translationally-Controlled 1
TI  - Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy.
TY  - research article
VL  - 13
ER  -