RT Journal Article
T1 Metabolically Healthy Obesity: Presence of Arterial Stiffness in the Prepubescent Population
A1 Ruiz-Moreno, Maria Isabel
A1 Vilches-Perez, Alberto
A1 Gallardo-Escribano, Cristina
A1 Vargas-Candela, Antonio
A1 Lopez-Carmona, Maria Dolores
A1 Pérez-Belmonte, Luis Miguel
A1 Ruiz-Moreno, Alejandro
A1 Gómez-Huelgas, Ricardo
A1 Bernal-Lopez, Maria Rosa
K1 Arterial stiffness
K1 Carotid-femoral pulse wave velocity
K1 Prepubescent population
K1 Mediterranean diet
K1 Insulin resistance
K1 Metabolically healthy obesity
K1 Rigidez vascular
K1 Velocidad de la onda del pulso carotídeo-femoral
K1 Dieta mediterránea
K1 Resistencia a la insulina
K1 Obesidad metabólica benigna
AB Aim: Arteriosclerotic cardiovascular disease, one of the world’s leading causes of death, first manifests itself at an early age. The identification of children who may have increased cardiovascular risk in the future could be an important prevention strategy. Our aim was to assess the clinical, analytical, and dietary variables associated with arterial stiffness (AS), measured by carotid-femoral pulse wave velocity (cfPWV) in a prepubescent population with metabolically healthy obesity (MHO). Subjects and Methods: A cross-sectional study in prepubescent subjects with obesity who had ≤1 metabolic syndrome criteria (abdominal perimeter and blood pressure ≥90th percentile, triglycerides >150 mg/dL, HDL-cholesterol < 0.0001), BMI (r = 0.44; p < 0.0001), WHtR (r = 0.26; p = 0.02), fasting insulin levels (r = 0.28; p = 0.02), and insulin resistance (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index) (r = 0.25; p = 0.04). Multiple linear regression analysis identified BMI and HOMA-IR as independent parameters associated with cfPWV. Conclusions: Prepubescent children with obesity who were shown to be metabolically healthy presented with arterial stiffness, which is closely related to BMI and the state of insulin resistance.
PB MDPI
SN 1661-7827
YR 2020
FD 2020-09-24
LK http://hdl.handle.net/10668/4377
UL http://hdl.handle.net/10668/4377
LA en
NO Ruiz-Moreno MI, Vilches-Perez A, Gallardo-Escribano C, Vargas-Candela A, Lopez-Carmona MD, Pérez-Belmonte LM, et al. Metabolically Healthy Obesity: Presence of Arterial Stiffness in the Prepubescent Population. Int J Environ Res Public Health. 2020 Sep 24;17(19):6995
DS RISalud
RD Apr 12, 2025