RT Journal Article
T1 Expert opinion paper on the treatment of hemophilia B with albutrepenonacog alfa.
A1 Alvarez-Roman, Maria Teresa
A1 Benitez, Olga
A1 Canaro, Maria Isabel
A1 Lopez-Fernandez, Maria Fernanda
A1 Lopez-Jaime, Francisco J
A1 Mateo-Arranz, Jose
A1 Nuñez, Ramiro
A1 Rodriguez-Lopez, Manuel
A1 Sierra-Aisa, Cristina
A1 Jimenez-Yuste, Victor
K1 Albutrepenonacog alfa
K1 Blood coagulation factors
K1 Factor IX
K1 Hemophilia B
K1 Qualitative research
AB Introduction: Current guidelines recommend prophylactic treatment of hemophilia B with the missing coagulation factor IX, either with standard half-life or extended half-life products. Extended half-life products have half-lives three to six times longer than the former, allowing a reduction in the number of weekly injections and therefore, potentially impacting on treatment adherence and quality of life. Albutrepenonacog alfa is an extended half-life fusion protein of coagulation factor IX with recombinant human albumin, indicated for both on-demand and prophylactic treatment for bleeding in patients with hemophilia B of all ages.Areas covered: The authors review the clinical and pharmacokinetic characteristics of albutrepenonacog alfa, as well as the available information regarding trough levels and real-world evidence. Given the availability of other factor IX products in the market, indirect comparisons of clinical and pharmacokinetic characteristics are presented.Expert opinion: The authors exhibit their expert opinion on which patient profiles are candidates for prophylactic treatment with albutrepenonacog alfa, and on the management of patients in terms of dosing, regimens of administration and protocols for switching the treatment.
PB Taylor & Francis
YR 2021
FD 2021-05-17
LK http://hdl.handle.net/10668/18164
UL http://hdl.handle.net/10668/18164
LA en
NO Álvarez Román MT, Benítez O, Canaro MI, López Fernández MF, López Jaime FJ, Mateo Arranz J, et al. Expert opinion paper on the treatment of hemophilia B with albutrepenonacog alfa. Expert Opin Biol Ther. 2021 Sep;21(9):1165-1171
DS RISalud
RD Apr 10, 2025