RT Journal Article
T1 Low serum iron levels and risk of cardiovascular disease in high risk elderly population: Nested case-control study in the PREvención con DIeta MEDiterránea (PREDIMED) trial.
A1 Gutierrez-Bedmar, Mario
A1 Olmedo, Pablo
A1 Gil, Fernando
A1 Ruiz-Canela, Miguel
A1 Martínez-González, Miguel A
A1 Salas-Salvadó, Jordi
A1 Babio, Nancy
A1 Fito, Montserrat
A1 Del Val, Jose L
A1 Corella, Dolores
A1 Sorli, Jose V
A1 Ros, Emilio
A1 Fiol, Miquel
A1 Estruch, Ramón
A1 Lapetra, José
A1 Arós, Fernando
A1 Serra-Majem, Luis
A1 Pintó, Xavier
A1 Gomez-Gracia, Enrique
K1 Cardiovascular disease
K1 Older populations
K1 PREDIMED
K1 Prospective studies
K1 Serum iron
AB Epidemiological data on iron status and cardiovascular disease (CVD) are still controversial. The aim of this study was to determine whether low serum iron (SI) levels are associated with an increased odds of first CVD event in a population at high cardiovascular risk. Case-control study design nested within the "PREvención con DIeta MEDiterránea" (PREDIMED) trial. A total of 207 participants diagnosed with CVD (myocardial infarction, stroke or cardiovascular death) during follow-up period (2003-2010) were matched by sex, age and intervention group to 436 controls by incidence density sampling. Median time between serum sample collection and subsequent CVD event occurrence was 0.94 years. Inductively coupled plasma mass spectrometry analysis was used to determine SI levels. In-person interviews, medical record reviews, and validated questionnaires were used to assess covariates. Multivariable-adjusted odds ratios (ORs) of CVD were calculated with conditional logistic regression. Mean SI levels were higher in men than in women (1224.0 μg/L vs. 1093.8 μg/L; p  The present findings are consistent with previously reported inverse associations between SI and CVD. SI levels as an independent marker of short-term cardiovascular risk may be useful for risk assessment in older populations. www.controlled-trials.com; International Standard Randomized Controlled Trial Number (ISRCTN): 35,739,639. Registered 5 October 2005. Retrospectively registered.
YR 2020
FD 2020-06-12
LK http://hdl.handle.net/10668/15835
UL http://hdl.handle.net/10668/15835
LA en
DS RISalud
RD Apr 10, 2025