RT Journal Article
T1 All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997-2010.
A1 Hernando, Victoria
A1 Alejos, Belén
A1 Monge, Susana
A1 Berenguer, Juan
A1 Anta, Lourdes
A1 Vinuesa, David
A1 Palacios, Rosario
A1 Muga, Roberto
A1 Moreno, Santiago
A1 Jarrin, Inma
K1 Mortality rate
K1 HIV infection
K1 Standardized mortality ratios
K1 Excess mortality
K1 Tasa de mortalidad
K1 Síndrome de inmunodeficiencia adquirida
K1 Estudios de cohortes
AB BACKGROUNDCombination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population.METHODSWe analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 person-years (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender.RESULTSBetween 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997-2003).CONCLUSIONMortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection.
PB BioMedCentral
YR 2013
FD 2013-08
LK http://hdl.handle.net/10668/1949
UL http://hdl.handle.net/10668/1949
LA en
NO Hernando V, Alejos B, Monge S, Berenguer J, Anta L, Vinuesa D, et al. All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997-2010. BMC Infect. Dis.2013; 13:382
NO Comparative Study; Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 8, 2025