RT Journal Article
T1 Coronary plaque burden, plaque characterization and their prognostic implications in familial hypercholesterolemia: A computed tomographic angiography study.
A1 Pérez de Isla, Leopoldo
A1 Alonso, Rodrigo
A1 Gómez de Diego, José Juan
A1 Muñiz-Grijalvo, Ovidio
A1 Díaz-Díaz, José Luis
A1 Zambón, Daniel
A1 Miramontes, José Pablo
A1 Fuentes, Francisco
A1 de Andrés, Raimundo
A1 Werenitzky, José
A1 Padró, Teresa
A1 Saltijeral, Adriana
A1 Mata, Pedro
A1 SAFEHEART investigators, 
K1 Cardiovascular events
K1 Coronary CTA
K1 Coronary artery disease
K1 Coronary plaque burden
K1 Familial hypercholesterolaemia
K1 Plaque characterization
K1 Prognosis
AB Heterozygous familial hypercholesterolemia (FH) is associated with premature atherosclerotic cardiovascular disease. Semi-automated plaque characterization (SAPC) by coronary computed tomographic angiography (CTA) provides information regarding coronary plaque burden and plaque characterization. Our aim was to quantify and characterize the coronary plaque burden of patients with FH using SAPC analysis and to identify which factors are related to plaque burden and plaque characteristics. A second aim was to analyse the prognostic implications of these parameters. Two hundred and fifty-nine asymptomatic individuals with molecularly determined FH were enrolled in this follow-up cohort study and underwent a coronary CTA analysed with SAPC. Mean follow-up time after coronary CTA was 3.9 ± 2 years. Mean age was 46.9 (10.7) years (130 women, 50.2%). Median plaque burden was 25.0% (19.0-29.0), non-calcified plaque burden 22.83% (17.94-26.88), calcified plaque-burden 1.12% (0.31-2.86) and CCS 8.9 (0-93). Five-year risk was independently related to plaque burden, non-calcified plaque burden, calcified plaque burden and coronary calcium score (B:3.75, 95%CI:2.92-4.58; p  Coronary atherosclerosis and its qualitative components may be quantified by means of SAPC in patients with FH. Plaque burden, calcified plaque burden and non-calcified plaque burden were independently related to the estimated cardiovascular risk. Plaque burden was also related to prognosis.
YR 2020
FD 2020-11-18
LK https://hdl.handle.net/10668/25713
UL https://hdl.handle.net/10668/25713
LA en
DS RISalud
RD Apr 17, 2025