RT Journal Article
T1 Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis.
A1 Gonzalo, Elena
A1 Toldos, Oscar
A1 Martínez-Vidal, María P
A1 Ordoñez, María C
A1 Santiago, Begoña
A1 Fernández-Nebro, Antonio
A1 Loza, Estíbaliz
A1 García, Isabel
A1 León, Myriam
A1 Pablos, José L
A1 Galindo, María
K1 Activación de Complemento
K1 Inmunohistoquímica
K1 Inflamación
K1 Riñón
K1 Nefritis Lúpica
K1 Macrófagos
K1 Fragmentos de Péptidos
K1 Trombosis
AB INTRODUCTIONMicrothrombosis is often observed in lupus nephritis (LN) lesions, but its clinical significance is unknown. We evaluated the clinicopathologic correlations of renal microthrombosis and inflammatory markers in LN.METHODSKidney biopsies from 58 patients with systemic lupus erythematosus (SLE) proliferative nephritis were analyzed with immunohistochemistry (IHC) for intravascular platelet aggregates (CD61), macrophagic infiltration (CD68), and activated complement deposition (C4d). Clinical data at the time of kidney biopsy and follow-up were analyzed with regard to pathologic IHC data.RESULTSMicrothrombosis was present in 52% of the tissues. It was significantly more prevalent in patients with antiphospholipid antibodies (aPLs) (62% versus 42%). The presence of microthrombosis significantly correlated with higher macrophagic infiltration. Macrophagic infiltration but not microthrombosis was significantly correlated with C4d deposition. Only macrophagic infiltration showed a correlation with SLE and renal activity (proteinuria and active sediment), whereas neither the presence of CD61+ microthrombi nor the extent of C4d deposition correlated with LN severity or outcome.CONCLUSIONSMicrothrombosis is associated with higher macrophagic infiltration in LN but does not seem to increase independently the severity of renal damage. Macrophagic infiltration was the best marker of SLE and renal activity in this LN series.
PB BiomedCentral
PB Springer Verlag (Germany)
SN 1478-6354
YR 2012
FD 2012-05-28
LK http://hdl.handle.net/10668/1448
UL http://hdl.handle.net/10668/1448
LA en
NO Gonzalo E, Toldos O, Martínez-Vidal MP, Ordoñez MC, Santiago B, Fernández-Nebro A, et al. Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis. Arthritis Res. Ther. 2012; 14(3):R126
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 10, 2025