RT Journal Article
T1 Effect of age at onset on cortical thickness and cognition in posterior cortical atrophy.
A1 Suárez-González, Aida
A1 Lehmann, Manja
A1 Shakespeare, Timothy J
A1 Yong, Keir X X
A1 Paterson, Ross W
A1 Slattery, Catherine F
A1 Foulkes, Alexander J M
A1 Rabinovici, Gil D
A1 Gil-Néciga, Eulogio
A1 Roldán-Lora, Florinda
A1 Schott, Jonathan M
A1 Fox, Nick C
A1 Crutch, Sebastian J
K1 Age at onset
K1 Atypical Alzheimer disease
K1 Cortical thickness
K1 Neuroimaging
K1 Posterior cortical atrophy
AB Age at onset (AAO) has been shown to influence the phenotype of Alzheimer's disease (AD), but how it affects atypical presentations of AD remains unknown. Posterior cortical atrophy (PCA) is the most common form of atypical AD. In this study, we aimed to investigate the effect of AAO on cortical thickness and cognitive function in 98 PCA patients. We used Freesurfer (v5.3.0) to compare cortical thickness with AAO both as a continuous variable, and by dichotomizing the groups based on median age (58 years). In both the continuous and dichotomized analyses, we found a pattern suggestive of thinner cortex in precuneus and parietal areas in earlier-onset PCA, and lower cortical thickness in anterior cingulate and prefrontal cortex in later-onset PCA. These cortical thickness differences between PCA subgroups were consistent with earlier-onset PCA patients performing worse on cognitive tests involving parietal functions. Our results provide a suggestion that AAO may not only affect the clinico-anatomical characteristics in AD but may also affect atrophy patterns and cognition within atypical AD phenotypes.
YR 2016
FD 2016-04-25
LK http://hdl.handle.net/10668/10188
UL http://hdl.handle.net/10668/10188
LA en
DS RISalud
RD Apr 17, 2025