RT Journal Article
T1 From Grafts to Human Bioengineered Vascularized Skin Substitutes
A1 Oualla-Bachiri, Wasima
A1 Fernández-González, Ana
A1 Quiñones-Vico, María I.
A1 Arias-Santiago, Salvador
K1 Angiogenesis
K1 Endothelial cells
K1 Grafts
K1 Skin substitutes
K1 Tissue engineering
K1 Trilayered
K1 Vascularization
K1 Wound healing
K1 Inductores de la angiogénesis
K1 Células Endoteliales
K1 Trasplantes
K1 Piel Artificial
AB The skin plays an important role in the maintenance of the human's body physiological homeostasis. It acts as a coverage that protects against infective microorganism or biomechanical impacts. Skin is also implied in thermal regulation and fluid balance. However, skin can suffer several damages that impede normal wound-healing responses and lead to chronic wounds. Since the use of autografts, allografts, and xenografts present source limitations and intense rejection associated problems, bioengineered artificial skin substitutes (BASS) have emerged as a promising solution to address these problems. Despite this, currently available skin substitutes have many drawbacks, and an ideal skin substitute has not been developed yet. The advances that have been produced on tissue engineering techniques have enabled improving and developing new arising skin substitutes. The aim of this review is to outline these advances, including commercially available skin substitutes, to finally focus on future tissue engineering perspectives leading to the creation of autologous prevascularized skin equivalents with a hypodermal-like layer to achieve an exemplary skin substitute that fulfills all the biological characteristics of native skin and contributes to wound healing.
PB MDPI
YR 2020
FD 2020-11-02
LK http://hdl.handle.net/10668/3706
UL http://hdl.handle.net/10668/3706
LA en
NO Oualla-Bachiri W, Fernández-González A, Quiñones-Vico MI, Arias-Santiago S. From Grafts to Human Bioengineered Vascularized Skin Substitutes. Int J Mol Sci. 2020 Nov 2;21(21):8197
DS RISalud
RD Apr 6, 2025