RT Journal Article
T1 Adenosine and preeclampsia.
A1 Salsoso, Rocio
A1 Farias, Marcelo
A1 Gutierrez, Jaime
A1 Pardo, Fabian
A1 Chiarello, Delia I
A1 Toledo, Fernando
A1 Leiva, Andrea
A1 Mate, Alfonso
A1 Vazquez, Carmen M
A1 Sobrevia, Luis
K1 Adenosine
K1 Adenosine receptor
K1 Endothelium
K1 Placenta
K1 Preeclampsia
K1 Trophoblast
AB Adenosine is an endogenous nucleoside with pleiotropic effects in different physiological processes including circulation, renal blood flow, immune function, or glucose homeostasis. Changes in adenosine membrane transporters, adenosine receptors, and corresponding intracellular signalling network associate with development of pathologies of pregnancy, including preeclampsia. Preeclampsia is a cause of maternal and perinatal morbidity and mortality affecting 3-5% of pregnancies. Since the proposed mechanisms of preeclampsia development include adenosine-dependent biological effects, adenosine membrane transporters and receptors, and the associated signalling mechanisms might play a role in the pathophysiology of preeclampsia. Preeclampsia associates with increased adenosine concentration in the maternal blood and placental tissue, likely due to local hypoxia and ischemia (although not directly demonstrated), microthrombosis, increased catecholamine release, and platelet activation. In addition, abnormal expression and function of equilibrative nucleoside transporters is described in foetoplacental tissues from preeclampsia; however, the role of adenosine receptors in the aetiology of this disease is not well understood. Adenosine receptors activation may be related to abnormal trophoblast invasion, angiogenesis, and ischemia/reperfusion mechanisms in the placenta from preeclampsia. These mechanisms may explain only a low fraction of the associated abnormal transformation of spiral arteries in preeclampsia, triggering cellular stress and inflammatory mediators release from the placenta to the maternal circulation. Although increased adenosine concentration in preeclampsia may be a compensatory or adaptive mechanism favouring placental angiogenesis, a poor angiogenic state is found in preeclampsia. Thus, preeclampsia-associated complications might affect the cell response to adenosine due to altered expression and activity of adenosine receptors, membrane transporters, or cell signalling mechanisms. This review summarizes the evidence available on the potential involvement of the adenosine in the clinical, pathophysiology, and therapeutic features of preeclampsia.
PB Elsevier Ltd
YR 2017
FD 2017-01-12
LK http://hdl.handle.net/10668/10777
UL http://hdl.handle.net/10668/10777
LA en
NO Salsoso R, Farías M, Gutiérrez J, Pardo F, Chiarello DI, Toledo F, et al. Adenosine and preeclampsia. Mol Aspects Med. 2017 Jun;55:126-139.
DS RISalud
RD Apr 19, 2025