RT Journal Article
T1 Association between sleep-disordered breathing and breast cancer aggressiveness.
A1 Campos-Rodriguez, Francisco
A1 Cruz-Medina, Antonio
A1 Selma, Maria Jose
A1 Rodriguez-de-la-Borbolla-Artacho, Maria
A1 Sanchez-Vega, Adrian
A1 Ripoll-Orts, Francisco
A1 Almeida-Gonzalez, Carmen V
A1 Martinez-Garcia, Miguel Angel
K1 Adult
K1 Comorbidity
K1 Humans
K1 Neoplasm Staging
K1 Postmenopause
K1 Severity of Illness Index
AB Sleep-disordered breathing (SDB) has been associated with cancer aggressiveness, but studies focused on specific tumors are lacking. In this pilot study we investigated whether SDB is associated with breast cancer (BC) aggressiveness. Methods 83 consecutive women <65 years diagnosed with primary BC underwent a home respiratory polygraphy. Markers of SDB severity included the apnea-hypopnea index (AHI) and the 4% oxygen desaturation index (ODI4). The Ki67 proliferation index, lack of hormone receptors (HR-), Nottingham Histological Grade (NHG), and tumor stage were used as markers of BC aggressiveness. The association between SDB and molecular subtypes of BC was also assessed. Results The mean (SD) age was 48.8 (8.8) years and body mass index was 27.4 (5.4) Kg/m2. 42 women (50.6%) were post-menopausal. The median (IQR) AHI was 5.1 (2–9.4), and ODI4 was 1.5 (0.5–5.8). The median (IQR) AHI did not differ between the groups with Ki67>28% and Ki67<29% [5.1 (2.6–8.3) vs 5.0 (1.5–10), p = 0.89)], HR- and HR+ [5.7 (1.6–12.4) vs 4.9 (2–9.4), p = 0.68], NHG (Grade3, Grade2, and Grade1; p = 0.86), tumor stage (stage III-IV, stage II, and stage I; p = 0.62), or molecular subtypes (Luminal A, Luminal B, HER2, and triple negative; p = 0.90). The prevalence of an AHI≥5 did not differ between the groups with Ki67>28% and Ki67<29% (51.2% vs 52.3%, p = 0.90), HR- and HR+ (58.3% vs 49.1%, p = 0.47), NHG categories (p = 0.89), different tumor stages (p = 0.71), or molecular subtypes (p = 0.73). These results did not change when the ODI4 was used instead of the AHI. Conclusion Our results do not support an association between the presence or severity of SDB and BC aggressiveness.
PB Public Library of Science
YR 2018
FD 2018-11-21
LK http://hdl.handle.net/10668/13218
UL http://hdl.handle.net/10668/13218
LA en
NO Campos-Rodriguez F, Cruz-Medina A, Selma MJ, Rodriguez-de-la-Borbolla-Artacho M, Sanchez-Vega A, et al. Association between sleep-disordered breathing and breast cancer aggressiveness. PLoS One. 2018 Nov 21;13(11):e0207591.
DS RISalud
RD Apr 10, 2025