RT Journal Article
T1 The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours.
A1 Millón, Carmelo
A1 Flores-Burgess, Antonio
A1 Narváez, Manuel
A1 Borroto-Escuela, Dasiel O
A1 Gago, Belén
A1 Santín, Luis
A1 Castilla-Ortega, Estela
A1 Narváez, José Ángel
A1 Fuxe, Kjell
A1 Díaz-Cabiale, Zaida
K1 Depression
K1 Galanin
AB Galanin is a 29 amino acid neuropeptide widely distributed in neurons within the central nervous system. Galanin exerts its biological activities through three different G protein-receptors and participates in a number of functions, including mood regulation. Not only Galanin but also Galanin N-terminal fragments like Galanin(1-15) are active at the central level. In this work, we review the latest findings in studies on Galanin and Galanin(1-15) in depression-related behaviours. Our focus is on animal models for depression, and we pay some attention to research data obtained in human studies. Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL1-GAL2-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression.
YR 2017
FD 2017-01-31
LK http://hdl.handle.net/10668/10865
UL http://hdl.handle.net/10668/10865
LA en
DS RISalud
RD Apr 19, 2025