%0 Journal Article
%A Millón, Carmelo
%A Flores-Burgess, Antonio
%A Narváez, Manuel
%A Borroto-Escuela, Dasiel O
%A Gago, Belén
%A Santín, Luis
%A Castilla-Ortega, Estela
%A Narváez, José Ángel
%A Fuxe, Kjell
%A Díaz-Cabiale, Zaida
%T The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours.
%D 2017
%U http://hdl.handle.net/10668/10865
%X Galanin is a 29 amino acid neuropeptide widely distributed in neurons within the central nervous system. Galanin exerts its biological activities through three different G protein-receptors and participates in a number of functions, including mood regulation. Not only Galanin but also Galanin N-terminal fragments like Galanin(1-15) are active at the central level. In this work, we review the latest findings in studies on Galanin and Galanin(1-15) in depression-related behaviours. Our focus is on animal models for depression, and we pay some attention to research data obtained in human studies. Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL1-GAL2-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression.
%K Depression
%K Galanin
%~