TY - JOUR AU - Ortega-García, María Belén AU - Mesa, Alberto AU - Moya, Elisa L. J. AU - Rueda, Beatriz AU - Lopez-Ordoño, Gabriel AU - García, Javier Ángel AU - Conde, Verónica AU - Redondo-Cerezo, Eduardo AU - Lopez-Hidalgo, Javier Luis AU - Jiménez, Gema AU - Peran, Macarena AU - Martínez-González, Luis J. AU - Del Val, Coral AU - Zwir, Igor AU - Marchal, Juan Antonio AU - García, María Ángel PY - 2020 DO - 10.3390/cancers12020379 UR - http://hdl.handle.net/10668/4547 T2 - Cancers AB - Colorectal cancer treatment has advanced over the past decade. The drug 5-fluorouracil is still used with a wide percentage of patients who do not respond. Therefore, a challenge is the identification of predictive biomarkers. The protein kinase R... LA - en PB - MDPI KW - Colorectal cancer KW - 5-fluorouracil-based chemotherapy KW - Protein kinase PKR KW - Non-coding nc886 KW - Ambispective study KW - Cluster of patients KW - Biomarkers KW - Chemotherapy KW - Neoplasias colorrectales KW - Fluorouracilo KW - Proteína quinasa PKR KW - Biomarcadores KW - Quimioterapia KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::Immunohistochemistry KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Cluster Analysis KW - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidinones::Uracil::Fluorouracil KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases KW - Medical Subject Headings::Phenomena and Processes::Mathematical Concepts::Algorithms KW - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Combined Modality Therapy::Chemotherapy, Adjuvant TI - Uncovering Tumour Heterogeneity through PKR and nc886 Analysis in Metastatic Colon Cancer Patients Treated with 5-FU-Based Chemotherapy TY - research article ER -