%0 Journal Article
%A Nguyen, Ai-Lan
%A Havrdova, Eva Kubala
%A Horakova, Dana
%A Izquierdo, Guillermo
%A Kalincik, Tomas
%A van der Walt, Anneke
%A Terzi, Murat
%A Alroughani, Raed
%A Duquette, Pierre
%A Girard, Marc
%A Prat, Alexandre
%A Boz, Cavit
%A Sola, Patrizia
%A Ferraro, Diana
%A Lugaresi, Alessandra
%A Lechner-Scott, Jeannette
%A Barnett, Michael
%A Grand'Maison, Francois
%A Grammond, Pierre
%A Ramo-Tello, Cristina
%A Turkoglu, Recai
%A McCombe, Pamela
%A Pucci, Eugenio
%A Trojano, Maria
%A Granella, Franco
%A Spitaleri, Daniele
%A Van Pesch, Vincent
%A Soysal, Aysun
%A Oreja-Guevara, Celia
%A Verheul, Freek
%A Vucic, Steve
%A Hodgkinson, Suzanne
%A Slee, Mark
%A Ampapa, Radek
%A Prevost, Julie
%A Menoyo, Jose Luis Sanchez
%A Skibina, Olga
%A Solaro, Claudio
%A Olascoaga, Javier
%A Shaw, Cameron
%A Madsen, Klaus Gregaard
%A Naidoo, Kerisha
%A Hyde, Robert
%A Butzkueven, Helmut
%A Jokubaitis, Vilija
%A MSBase Study Group
%T Incidence of pregnancy and disease-modifying therapy exposure trends in women with multiple sclerosis: A contemporary cohort study.
%D 2019
%U http://hdl.handle.net/10668/13395
%X Exposure to disease-modifying therapy (DMT) during early pregnancy in women with relapsing-remitting MS (RRMS) may be increasing. To retrospectively determine incidence of pregnancy, DMT exposure and pregnancy outcomes in women with RRMS. We identified all women with RRMS aged 15-45 years in the MSBase Registry between 2005-2016. Annualised pregnancy incidence rates were calculated using Poisson regression models. DMT exposures and pregnancy outcomes were assessed. Of 9,098 women meeting inclusion criteria, 1,178 (13%) women recorded 1,521 pregnancies. The annualised incidence rate of pregnancy was 0.042 (95% CI 0.040, 0.045). A total of 635 (42%) reported pregnancies were conceived on DMT, increasing from 27% in 2006 to 62% in 2016. The median duration of DMT exposure during pregnancy was 30 days (IQR: 9, 50). There were a higher number of induced abortions on FDA pregnancy class C/D drugs compared with pregnancy class B and no DMT (p = 0.010); but no differences in spontaneous abortions, term or preterm births. We report low pregnancy incidence rates, with increasing number of pregnancies conceived on DMT over the past 12-years. The median duration of DMT exposure in pregnancy was relatively short at one month.
%K Incidence
%K Multiple sclerosis
%K Outcomes
%K Pregnancy
%K Therapy
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