RT Journal Article
T1 Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test.
A1 Sandoval-Alzate, Hector Fabio
A1 Agudelo-Zapata, Yessica
A1 Gonzalez-Clavijo, Angelica Maria
A1 Poveda, Natalia E
A1 Espinel-Pachon, Cristian Felipe
A1 Escamilla-Castro, Jorge Augusto
A1 Marquez-Julio, Heidy Lorena
A1 Alvarado-Quintero, Hernando
A1 Rojas-Rodriguez, Fabian Guillermo
A1 Arteaga-Diaz, Juan Manuel
A1 Eslava-Schmalbach, Javier Hernando
A1 Garces-Gutierrez, Maria Fernanda
A1 Vrontakis, Maria
A1 Castaño, Justo P
A1 Luque, Raul M
A1 Dieguez, Carlos
A1 Nogueiras, Ruben
A1 Caminos, Jorge E
K1 Adult
K1 Blood glucose
K1 Body mass index
K1 Cross-sectional studies
AB Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m(2)) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m(2)). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p p<0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA–IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120minutes during the OGTT is the most predictive variable for serum GAL levels (p<0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.
PB Nature Publishing Group
YR 2016
FD 2016-07-18
LK http://hdl.handle.net/10668/10385
UL http://hdl.handle.net/10668/10385
LA en
NO Sandoval-Alzate HF, Agudelo-Zapata Y, González-Clavijo AM, Poveda NE, Espinel-Pachón CF, Escamilla-Castro JA, et al.  Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test. Sci Rep. 2016 Aug 23;6:31661
NO This study was supported by research grants from Colciencias–Government of Colombia (Project: 110165740394) and the Universidad Nacional de Colombia. Additional support was provided by: Xunta de Galicia (R.N.: 2015-CP080) and MINECO co-funded by the FEDER Program of EU (C.D.: BFU2014-5587; R.N.: BFU2015-70664-R), MINECO (BFU2013-43282-R), Instituto de Salud Carlos III (PI13-00651), Junta de Andalucía (BIO-0139, CTS1406), and CIBERobn
DS RISalud
RD Apr 5, 2025