RT Journal Article T1 High-Dimensional Analysis of Single-Cell Flow Cytometry Data Predicts Relapse in Childhood Acute Lymphoblastic Leukaemia. A1 Chulián, Salvador A1 Martínez-Rubio, Álvaro A1 Pérez-García, Víctor M A1 Rosa, María A1 Blázquez Goñi, Cristina A1 Rodríguez Gutiérrez, Juan Francisco A1 Hermosín-Ramos, Lourdes A1 Molinos Quintana, Águeda A1 Caballero-Velázquez, Teresa A1 Ramírez-Orellana, Manuel A1 Castillo Robleda, Ana A1 Fernández-Martínez, Juan Luis K1 Acute Lymphoblastic Leukaemia K1 CD38 K1 Fisher’s Ratio K1 flow cytometry data K1 mathematical oncology K1 personalised medicine K1 response biomarkers AB Artificial intelligence methods may help in unveiling information that is hidden in high-dimensional oncological data. Flow cytometry studies of haematological malignancies provide quantitative data with the potential to be used for the construction of response biomarkers. Many computational methods from the bioinformatics toolbox can be applied to these data, but they have not been exploited in their full potential in leukaemias, specifically for the case of childhood B-cell Acute Lymphoblastic Leukaemia. In this paper, we analysed flow cytometry data that were obtained at diagnosis from 56 paediatric B-cell Acute Lymphoblastic Leukaemia patients from two local institutions. Our aim was to assess the prognostic potential of immunophenotypical marker expression intensity. We constructed classifiers that are based on the Fisher's Ratio to quantify differences between patients with relapsing and non-relapsing disease. We also correlated this with genetic information. The main result that arises from the data was the association between subexpression of marker CD38 and the probability of relapse. SN 2072-6694 YR 2020 FD 2020-12-23 LK https://hdl.handle.net/10668/25117 UL https://hdl.handle.net/10668/25117 LA en DS RISalud RD Sep 4, 2025