RT Journal Article
T1 Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma.
A1 Carrera, Caty
A1 Cárcel-Márquez, Jara
A1 Cullell, Natalia
A1 Torres-Águila, Nuria
A1 Muiño, Elena
A1 Castillo, José
A1 Sobrino, Tomás
A1 Campos, Francisco
A1 Rodríguez-Castro, Emilio
A1 Llucià-Carol, Laia
A1 Millán, Mònica
A1 Muñoz-Narbona, Lucía
A1 López-Cancio, Elena
A1 Bustamante, Alejandro
A1 Ribó, Marc
A1 Álvarez-Sabín, José
A1 Jiménez-Conde, Jordi
A1 Roquer, Jaume
A1 Giralt-Steinhauer, Eva
A1 Soriano-Tárraga, Carolina
A1 Mola-Caminal, Marina
A1 Vives-Bauza, Cristófol
A1 Navarro, Rosa Díaz
A1 Tur, Silvia
A1 Obach, Victor
A1 Arenillas, Juan Francisco
A1 Segura, Tomás
A1 Serrano-Heras, Gemma
A1 Martí-Fàbregas, Joan
A1 Delgado-Mederos, Raquel
A1 Freijo-Guerrero, M Mar
A1 Moniche, Francisco
A1 Cabezas, Juan Antonio
A1 Castellanos, Mar
A1 Gallego-Fabrega, Cristina
A1 González-Sanchez, Jonathan
A1 Krupinsky, Jurek
A1 Strbian, Daniel
A1 Tatlisumak, Turgut
A1 Thijs, Vincent
A1 Lemmens, Robin
A1 Slowik, Agnieszka
A1 Pera, Johanna
A1 Kittner, Steven
A1 Cole, John
A1 Heitsch, Laura
A1 Ibañez, Laura
A1 Cruchaga, Carlos
A1 Lee, Jin-Moo
A1 Montaner, Joan
A1 Fernández-Cadenas, Israel
K1 GWAS
K1 ischaemic stroke
K1 parenchymal haematoma
K1 pharmacogenetics
K1 thrombolysis
AB Haemorrhagic transformation is a complication of recombinant tissue-plasminogen activator treatment. The most severe form, parenchymal haematoma, can result in neurological deterioration, disability, and death. Our objective was to identify single nucleotide variations associated with a risk of parenchymal haematoma following thrombolytic therapy in patients with acute ischaemic stroke. A fixed-effect genome-wide meta-analysis was performed combining two-stage genome-wide association studies (n = 1904). The discovery stage (three cohorts) comprised 1324 ischaemic stroke individuals, 5.4% of whom had a parenchymal haematoma. Genetic variants yielding a P-value
YR 2021
FD 2021
LK https://hdl.handle.net/10668/27741
UL https://hdl.handle.net/10668/27741
LA en
DS RISalud
RD Apr 18, 2025