%0 Journal Article
%A Carrera, Caty
%A Cárcel-Márquez, Jara
%A Cullell, Natalia
%A Torres-Águila, Nuria
%A Muiño, Elena
%A Castillo, José
%A Sobrino, Tomás
%A Campos, Francisco
%A Rodríguez-Castro, Emilio
%A Llucià-Carol, Laia
%A Millán, Mònica
%A Muñoz-Narbona, Lucía
%A López-Cancio, Elena
%A Bustamante, Alejandro
%A Ribó, Marc
%A Álvarez-Sabín, José
%A Jiménez-Conde, Jordi
%A Roquer, Jaume
%A Giralt-Steinhauer, Eva
%A Soriano-Tárraga, Carolina
%A Mola-Caminal, Marina
%A Vives-Bauza, Cristófol
%A Navarro, Rosa Díaz
%A Tur, Silvia
%A Obach, Victor
%A Arenillas, Juan Francisco
%A Segura, Tomás
%A Serrano-Heras, Gemma
%A Martí-Fàbregas, Joan
%A Delgado-Mederos, Raquel
%A Freijo-Guerrero, M Mar
%A Moniche, Francisco
%A Cabezas, Juan Antonio
%A Castellanos, Mar
%A Gallego-Fabrega, Cristina
%A González-Sanchez, Jonathan
%A Krupinsky, Jurek
%A Strbian, Daniel
%A Tatlisumak, Turgut
%A Thijs, Vincent
%A Lemmens, Robin
%A Slowik, Agnieszka
%A Pera, Johanna
%A Kittner, Steven
%A Cole, John
%A Heitsch, Laura
%A Ibañez, Laura
%A Cruchaga, Carlos
%A Lee, Jin-Moo
%A Montaner, Joan
%A Fernández-Cadenas, Israel
%T Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma.
%D 2021
%U https://hdl.handle.net/10668/27741
%X Haemorrhagic transformation is a complication of recombinant tissue-plasminogen activator treatment. The most severe form, parenchymal haematoma, can result in neurological deterioration, disability, and death. Our objective was to identify single nucleotide variations associated with a risk of parenchymal haematoma following thrombolytic therapy in patients with acute ischaemic stroke. A fixed-effect genome-wide meta-analysis was performed combining two-stage genome-wide association studies (n = 1904). The discovery stage (three cohorts) comprised 1324 ischaemic stroke individuals, 5.4% of whom had a parenchymal haematoma. Genetic variants yielding a P-value
%K GWAS
%K ischaemic stroke
%K parenchymal haematoma
%K pharmacogenetics
%K thrombolysis
%~