RT Journal Article
T1 Thymic Function Failure Is Associated With Human Immunodeficiency Virus Disease Progression.
A1 Ferrando-Martinez, Sara
A1 De Pablo-Bernal, Rebeca S
A1 De Luna-Romero, Marta
A1 De Ory, Santiago J
A1 Genebat, Miguel
A1 Pacheco, Yolanda M
A1 Parras, Francisco J
A1 Montero, Marta
A1 Blanco, Jose Ramón
A1 Gutierrez, Felix
A1 Santos, Jesus
A1 Vidal, Francisco
A1 Koup, Richard A
A1 Muñoz-Fernández, María Ángeles
A1 Leal, Manuel
A1 Ruiz-Mateos, Ezequiel
K1 HIV disease progression
K1 LTNP
K1 sj/β-TREC ratio
K1 thymic function
K1 vertical infection
AB Thymic function has been mainly analyzed with surrogate peripheral markers affected by peripheral T-cell expansion, making it difficult to assess the role of thymic failure in human immunodeficiency virus (HIV) disease progression. The assay of signal-joint/DβJβ T-cell rearrangement excision circles (sj/β-TREC ratio) overcomes this limitation but has only been assayed in small cohorts. Thus, the aim of this study was to determine the role of thymic function, measured by the sj/β-TREC ratio, on CD4 T-cell maintenance in prospective HIV cohorts that include patients with a wide age range and different immunological phenotypes. Seven hundred seventy-four patients including typical progressors, long-term nonprogressors (LTNPs), and vertically HIV-infected subjects were analyzed. Thymic function was quantified in peripheral blood samples using the sj/β-TREC ratio. Associations between thymic function and CD4 T-cell dynamics and combination antiretroviral therapy (cART) onset were analyzed using linear, logistic, and Cox proportional hazard models. Thymic function failure (sj/β-TREC ratio  This work establishes the relevance of thymic function, measured by sj/β-TREC ratio, in HIV disease progression by analyzing a large number of patients in 3 cohorts with different HIV disease progression phenotypes. These results support and help to understand the mechanisms underlying the rationale of early cART onset.
YR 2017
FD 2017
LK http://hdl.handle.net/10668/10835
UL http://hdl.handle.net/10668/10835
LA en
DS RISalud
RD Apr 6, 2025