TY  - JOUR
AU  - Gasca, Jessica
AU  - Flores, Maria Luz
AU  - Giráldez, Servando
AU  - Ruiz-Borrego, Manuel
AU  - Tortolero, María
AU  - Romero, Francisco
AU  - Japón, Miguel A
AU  - Sáez, Carmen
PY  - 2016
DO  - 10.18632/oncotarget.10481
UR  - http://hdl.handle.net/10668/10265
T2  - Oncotarget
AB  - FBXW7 is a component of SCF (complex of SKP1, CUL1 and F-box-protein)-type ubiquitin ligases that targets several oncoproteins for ubiquitination and degradation by the proteasome. FBXW7 regulates cellular apoptosis by targeting MCL1 for...
LA  - en
KW  - FBXW7
KW  - MCL1
KW  - PLK1
KW  - Pathology Section
KW  - apoptosis
KW  - paclitaxel
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - Apoptosis
KW  - Breast Neoplasms
KW  - Cell Cycle
KW  - Cell Cycle Proteins
KW  - Cell Line, Tumor
KW  - Drug Resistance, Neoplasm
KW  - F-Box-WD Repeat-Containing Protein 7
KW  - Female
KW  - Humans
KW  - Kaplan-Meier Estimate
KW  - MCF-7 Cells
KW  - Myeloid Cell Leukemia Sequence 1 Protein
KW  - Paclitaxel
KW  - Protein Serine-Threonine Kinases
KW  - Proto-Oncogene Proteins
KW  - RNA Interference
TI  - Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer.
TY  - research article
VL  - 7
ER  -