RT Journal Article
RT null
T1 Synthesis, characterization and in vivo evaluation of biocompatible ferrogels
A1 Lopez-Lopez, M. T.
A1 Rodriguez, I. A.
A1 Rodriguez-Arco, L.
A1 Carriel, V.
A1 Bonhome-Espinosa, A. B.
A1 Campos, F.
A1 Zubarev, A.
A1 Duran, J. D. G.
K1 Ferrogel
K1 Polymer
K1 Magnetic particle
K1 Rheology
K1 Magnetorheology
K1 In vivo
K1 Nanoparticles
K1 Scaffolds
AB A hydrogel is a 3-D network of polymer chains in which water is the dispersion medium. Hydrogels have found extensive applications in the biomedical field due to their resemblance to living tissues. Furthermore, hydrogels can be endowed with exceptional properties by addition of synthetic materials. For example, magnetic field-sensitive gels, called ferrogels, are obtained by embedding magnetic particles in the polymer network. Novel living tissues with unique magnetic field-sensitive properties were recently prepared by 3-D cell culture in biocompatible ferrogels. This paper critically reviews the most recent progress and perspectives in their synthesis, characterization and biocompatibility evaluation. Optimization of ferrogels for this novel application requires low-density, strongly magnetic, multi-domain particles. Interestingly, the rheological properties of the resulting ferrogels in the absence of field were largely enhanced with respect to nonmagnetic hydrogels, which can only be explained by the additional cross-linking imparted by the embedded magnetic particles. Remarkably, rheological measurements under an applied magnetic field demonstrated that ferrogels presented reversibly tunable mechanical properties, which constitutes a unique advantage with respect to nonmagnetic hydrogels. In vivo evaluation of ferrogels showed good biocompatibility, with only some local inflammatory response, and no particle migration or damage to distant organs. (C) 2016 Elsevier B.V. All rights reserved.
PB Elsevier
PB Elsevier BV * North-Holland
SN 0304-8853
YR 2016
FD 2016-08-16
LK http://hdl.handle.net/10668/18826
UL http://hdl.handle.net/10668/18826
LA en
NO Lopez-Lopez MT, Rodriguez IA, Rodriguez-Arco L, Carriel V, Bonhome-Espinosa AB, Campos F, et al. Synthesis, characterization and in vivo evaluation of biocompatible ferrogels. J Magn Magn Mater. 2017;431:110-114
NO Financial support: projects FIS2013-41821-R and FIS PI14-1343 (MINECO, Spain; co-funded by ERDF, UE). AZ also acknowledges the Russian Scientific Foundation, project14-19-00989
DS RISalud
RD Apr 6, 2025