RT Journal Article
T1 The Paradox of Coenzyme Q10 in Aging.
A1 Díaz-Casado, M Elena
A1 Quiles, José L
A1 Barriocanal-Casado, Eliana
A1 González-García, Pilar
A1 Battino, Maurizio
A1 López, Luis C
A1 Varela-López, Alfonso
K1 aging-related diseases
K1 anti-aging
K1 antioxidant
K1 diet
K1 mitochondria
K1 mitohormesis
AB Coenzyme Q (CoQ) is an essential endogenously synthesized molecule that links different metabolic pathways to mitochondrial energy production thanks to its location in the mitochondrial inner membrane and its redox capacity, which also provide it with the capability to work as an antioxidant. Although defects in CoQ biosynthesis in human and mouse models cause CoQ deficiency syndrome, some animals models with particular defects in the CoQ biosynthetic pathway have shown an increase in life span, a fact that has been attributed to the concept of mitohormesis. Paradoxically, CoQ levels decline in some tissues in human and rodents during aging and coenzyme Q10 (CoQ10) supplementation has shown benefits as an anti-aging agent, especially under certain conditions associated with increased oxidative stress. Also, CoQ10 has shown therapeutic benefits in aging-related disorders, particularly in cardiovascular and metabolic diseases. Thus, we discuss the paradox of health benefits due to a defect in the CoQ biosynthetic pathway or exogenous supplementation of CoQ10.
YR 2019
FD 2019-09-14
LK http://hdl.handle.net/10668/14523
UL http://hdl.handle.net/10668/14523
LA en
DS RISalud
RD Apr 18, 2025