RT Journal Article
T1 Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans.
A1 Stepien, Magdalena
A1 Hughes, David J
A1 Hybsier, Sandra
A1 Bamia, Christina
A1 Tjønneland, Anne
A1 Overvad, Kim
A1 Affret, Aurélie
A1 His, Mathilde
A1 Boutron-Ruault, Marie-Christine
A1 Katzke, Verena
A1 Kühn, Tilman
A1 Aleksandrova, Krasimira
A1 Trichopoulou, Antonia
A1 Lagiou, Pagona
A1 Orfanos, Phlippos
A1 Palli, Domenico
A1 Sieri, Sabina
A1 Tumino, Rosario
A1 Ricceri, Fulvio
A1 Panico, Salvatore
A1 Bueno-de-Mesquita, H B As
A1 Peeters, Petra H
A1 Weiderpass, Elisabete
A1 Lasheras, Cristina
A1 Bonet Bonet, Catalina
A1 Molina-Portillo, Elena
A1 Dorronsoro, Miren
A1 Huerta, José María
A1 Barricarte, Aurelio
A1 Ohlsson, Bodil
A1 Sjöberg, Klas
A1 Werner, Mårten
A1 Shungin, Dmitry
A1 Wareham, Nick
A1 Khaw, Kay-Tee
A1 Travis, Ruth C
A1 Freisling, Heinz
A1 Cross, Amanda J
A1 Schomburg, Lutz
A1 Jenab, Mazda
AB Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n=106, IHDB n=34, GBTC n=96) and their matched controls (1:1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk. For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR=0.36; 95% CI: 0.13-0.98, Ptrend=0.0123), but no association for copper (OR=1.06; 95% CI: 0.45-2.46, Ptrend=0.8878) in multivariable models. The calculated Cu/Zn ratio showed a positive association for HCC (OR=4.63; 95% CI: 1.41-15.27, Ptrend=0.0135). For IHBC and GBTC, no significant associations were observed. Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.
YR 2017
FD 2017-02-02
LK http://hdl.handle.net/10668/10830
UL http://hdl.handle.net/10668/10830
LA en
DS RISalud
RD Apr 10, 2025