%0 Journal Article
%A Stepien, Magdalena
%A Hughes, David J
%A Hybsier, Sandra
%A Bamia, Christina
%A Tjønneland, Anne
%A Overvad, Kim
%A Affret, Aurélie
%A His, Mathilde
%A Boutron-Ruault, Marie-Christine
%A Katzke, Verena
%A Kühn, Tilman
%A Aleksandrova, Krasimira
%A Trichopoulou, Antonia
%A Lagiou, Pagona
%A Orfanos, Phlippos
%A Palli, Domenico
%A Sieri, Sabina
%A Tumino, Rosario
%A Ricceri, Fulvio
%A Panico, Salvatore
%A Bueno-de-Mesquita, H B As
%A Peeters, Petra H
%A Weiderpass, Elisabete
%A Lasheras, Cristina
%A Bonet Bonet, Catalina
%A Molina-Portillo, Elena
%A Dorronsoro, Miren
%A Huerta, José María
%A Barricarte, Aurelio
%A Ohlsson, Bodil
%A Sjöberg, Klas
%A Werner, Mårten
%A Shungin, Dmitry
%A Wareham, Nick
%A Khaw, Kay-Tee
%A Travis, Ruth C
%A Freisling, Heinz
%A Cross, Amanda J
%A Schomburg, Lutz
%A Jenab, Mazda
%T Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans.
%D 2017
%U http://hdl.handle.net/10668/10830
%X Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n=106, IHDB n=34, GBTC n=96) and their matched controls (1:1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk. For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR=0.36; 95% CI: 0.13-0.98, Ptrend=0.0123), but no association for copper (OR=1.06; 95% CI: 0.45-2.46, Ptrend=0.8878) in multivariable models. The calculated Cu/Zn ratio showed a positive association for HCC (OR=4.63; 95% CI: 1.41-15.27, Ptrend=0.0135). For IHBC and GBTC, no significant associations were observed. Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.
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