RT Journal Article
T1 Association between Radiotherapy and Risk of Cancer Associated Venous Thromboembolism: A Sub-Analysis of the COMPASS-CAT Study.
A1 Temraz, Sally
A1 Moukalled, Nour
A1 Gerotziafas, Grigorios T
A1 Elalamy, Ismail
A1 Jara-Palomares, Luis
A1 Charafeddine, Maya
A1 Taher, Ali
K1 neoplasms
K1 pulmonary embolism
K1 radiotherapy
K1 risk factors
K1 venous thromboembolism
AB The role and effect of radiotherapy in the development of VTE has not been extensively explored; Methods: This is a post-hoc analysis from the COMPASS-CAT trial. Patients with breast, lung, colon or ovarian cancer, with early, locally advanced or metastatic disease and receiving chemotherapy were included. Primary endpoint was documented symptomatic VTE; Results: A total of 1355 patients were enrolled between November 2013 and November 2015. Of those, 194 patients were excluded because of missing data or the use of anticoagulation. Of the evaluable patients, 361 patients received radiotherapy (33.6%) At a median follow up of 6 months, 9.1% (n = 33) of patients receiving radiotherapy developed a VTE event (excluding those with missing data on follow up). After applying the competing risk model, radiotherapy remained significantly associated with increased risk for VTE (HR 2.47, 95% CI: 1.47-4.12, p = 0.001). Stratification analysis for the cohort that received radiotherapy revealed an increased risk of VTE in women compared to men (10.8% vs. 2.7%; p = 0.03), in those older than 50 (12.2% vs. 3.7%; p = 0.011); for patients receiving anthracycline chemotherapy (14.4% vs. 2.9%; p
SN 2072-6694
YR 2021
FD 2021-03-02
LK http://hdl.handle.net/10668/17457
UL http://hdl.handle.net/10668/17457
LA en
DS RISalud
RD Apr 8, 2025