RT Journal Article
T1 Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis.
A1 Ruiz-Margáin, Astrid
A1 Macías-Rodríguez, Ricardo Ulises
A1 Ampuero, Javier
A1 Cubero, Francisco Javier
A1 Chi-Cervera, Luis
A1 Ríos-Torres, Silvia L
A1 Duarte-Rojo, Andrés
A1 Espinosa-Cuevas, Ángeles
A1 Romero-Gómez, Manuel
A1 Torre, Aldo
K1 Malnutrition
K1 Hepatic encephalopathy
K1 Phase angle
K1 Cachexia
K1 Prognosis
K1 Estudios de seguimiento
K1 Várices esofágicas y gástricas
K1 Encefalopatía hepática
K1 Hepatitis C
K1 Cirrosis hepática
K1 Modelos de riesgos proporcionales
K1 Análisis de regresión
AB AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the long-term follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. Mann-Whitney's U and χ(2) tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy.RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy (18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. Kaplan-Meier curves showed a higher proportion of HE in the group with low phase angle (39%) compared to the normal phase angle group (13%) (P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80 (1.07-3.03)].CONCLUSIONIn our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis.
PB Baishideng Publishing Group
SN 1007-9327
YR 2016
FD 2016-12-07
LK http://hdl.handle.net/10668/2598
UL http://hdl.handle.net/10668/2598
LA en
NO Ruiz-Margáin A, Macías-Rodríguez RU, Ampuero J, Cubero FJ, Chi-Cervera L, Ríos-Torres SL, et al. Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis. World J. Gastroenterol.. 2016; 22(45):10064-10070
NO Journal Article;
DS RISalud
RD Apr 19, 2025