TY - GEN AU - Fernandez-Calle, Rosalia AU - Konings, Sabine C AU - Frontiñan-Rubio, Javier AU - Garcia-Revilla, Juan AU - Camprubi-Ferrer, Lluis AU - Svensson, Martina AU - Martinson, Isak AU - Boza-Serrano, Antonio AU - Venero, Jose Luis AU - Nielsen, Henrietta M AU - Gouras, Gunnar K AU - Deierborg, Tomas PY - 2022 DO - 10.1186/s13024-022-00566-4 UR - http://hdl.handle.net/10668/20343 T2 - Molecular neurodegeneration AB - ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset... LA - en PB - BioMed Central Ltd. KW - Alzheimer’s disease KW - Apolipoprotein E KW - Neurodegeneration KW - Neuroinflammation KW - Humans KW - Alzheimer Disease KW - Amyloid beta-Peptides KW - Apolipoprotein E2 KW - Apolipoprotein E3 KW - Apolipoprotein E4 KW - Apolipoproteins E KW - Genotype KW - Neurodegenerative Diseases KW - Plaque, Amyloid KW - tau Proteins TI - APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases. TY - review VL - 17 ER -