RT Journal Article
T1 Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study.
A1 Huerta, José M
A1 Chirlaque, María Dolores
A1 Molina, Antonio J
A1 Amiano, Pilar
A1 Martín, Vicente
A1 Fernández-Villa, Tania
A1 Pérez-Gómez, Beatriz
A1 Moreno, Víctor
A1 Burgui, Rosana
A1 Gómez-Acebo, Inés
A1 Ramos-Lora, Manuel
A1 Fernández-Tardón, Guillermo
A1 Peiró, Rosana
A1 Olmedo-Requena, Rocío
A1 Pollán, Marina
A1 Kogevinas, Manolis
A1 Castaño-Vinyals, Gemma
A1 Aragonés, Nuria
A1 Navarro, 
AB Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study. 428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals' catchment areas. A physical activity (PA) questionnaire was used to gather information on household and recreational activities, allowing estimation of PA volume (in metabolic equivalents (MET)-min/week). Participants also reported the intensity of working PA and daily sitting time. Questionnaire data on diet, lifestyles and clinical variables including Helicobacter pylori serology were available. Adjusted odds ratios (OR) of GAC were estimated for domains of physical activity, stratifying by sex, site (cardia vs. non-cardia), and Lauren classification (intestinal vs. diffuse). Household physical activity (HPA) showed a strong inverse association with GAC, observed for both cardia and non-cardia tumours. Risk of overall gastric cancer was 50% lower risk among participants in the highest HPA category (OR = 0.50, 95%CI: 0.38, 0.66). Recreational physical activity (RPA) was also associated with lower overall GAC risk (OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79). The protective effect of RPA was strongest for non-cardia tumours. Sedentary time was not related to GAC risk (p-trend = 0.392), but the potential protective effect of RPA was restricted to non-sedentary participants. Both household and recreational physical activities were independently related to lower GAC risk in the MCC-Spain study.
YR 2017
FD 2017-07-06
LK http://hdl.handle.net/10668/11379
UL http://hdl.handle.net/10668/11379
LA en
DS RISalud
RD Apr 7, 2025