RT Journal Article
T1 Complement Factor C3 Methylation and mRNA Expression Is Associated to BMI and Insulin Resistance in Obesity.
A1 Castellano-Castillo, Daniel
A1 Moreno-Indias, Isabel
A1 Fernandez-Garcia, Jose Carlos
A1 Clemente-Postigo, Mercedes
A1 Castro-Cabezas, Manuel
A1 Tinahones, Francisco José
A1 Queipo-Ortuño, María Isabel
A1 Cardona, Fernando
K1 ASP
K1 C3
K1 DNA methylation
K1 complement factor
K1 insulin resistance
K1 obesity
AB Epigenetic marks, and especially DNA methylation, are becoming an important factor in obesity, which could help to explain its etiology and associated comorbidities. Adipose tissue, now considered as an important endocrine organ, produces complement system factors. Complement component 3 (C3) turns out to be an important protein in metabolic disorders, via either inflammation or the C3 subproduct acylation stimulating protein (ASP) which directly stimulates lipid storage. In this study, we analyze C3 DNA methylation in adipose tissue from subjects with a different grade of obesity. Adipose tissue samples were collected from subjects with a different degree of obesity determined by their body mass index (BMI) as: Overweight subjects (BMI ≥ 25 and
SN 2073-4425
YR 2018
FD 2018-08-13
LK https://hdl.handle.net/10668/26500
UL https://hdl.handle.net/10668/26500
LA en
DS RISalud
RD Apr 11, 2025